First Characterization of Novel Silicon Carbide Detectors with Ultra-High Dose Rate Electron Beams for FLASH Radiotherapy

被引:21
作者
Romano, Francesco [1 ,2 ]
Milluzzo, Giuliana [1 ]
Di Martino, Fabio [3 ,4 ]
D'Oca, Maria Cristina [1 ,5 ]
Felici, Giuseppe [6 ]
Galante, Federica [6 ]
Gasparini, Alessia [7 ,8 ]
Mariani, Giulia [6 ]
Marrale, Maurizio [1 ,5 ]
Medina, Elisabetta [9 ,10 ]
Pacitti, Matteo [6 ]
Sangregorio, Enrico [11 ,12 ]
Vanreusel, Verdi [8 ,13 ]
Verellen, Dirk [7 ,8 ]
Vignati, Anna [9 ,10 ]
Camarda, Massimo [14 ,15 ]
机构
[1] Ist Nazl Fis Nucl INFN, Sez Catania, I-95123 Catania, Italy
[2] Univ Groningen, Univ Med Ctr Groningen, Particle Therapy Res Ctr PARTREC, Dept Radiat Oncol, Zernikelaan 25, NL-9747 AA Groningen, Netherlands
[3] Presidio S Chiara, Ctr Pisano Ric & Implementaz Clin Flash Radiother, I-56126 Pisa, Italy
[4] Azienda Ospedaliero Univ Pisana, UO Fis Sanit, I-56126 Pisa, Italy
[5] Univ Palermo, Dipartimento Fis & Chim Emilio Segre, I-90128 Palermo, Italy
[6] SIT Sordina, I-36100 Vicenza, Italy
[7] Iridium Network Radiotherapy, B-2610 Antwerp, Belgium
[8] Univ Antwerp, Fac Med & Hlth Sci, B-2610 Antwerp, Belgium
[9] Univ Torino, Dipartimento Fis, I-10125 Turin, Italy
[10] INFN Sez Torino, I-10124 Turin, Italy
[11] Univ Catania, Dipartimento Fis & Astron, I-95124 Catania, Italy
[12] CNR Ist Microelettron & Microsistemi, I-95121 Catania, Italy
[13] SCK CEN Res Dosimetr Applicat, B-2400 Mol, Belgium
[14] STLab srl, Via Anapo 53, I-95126 Catania, Italy
[15] DeliveryLab, SenSiC, CH-5232 Villigen, Switzerland
来源
APPLIED SCIENCES-BASEL | 2023年 / 13卷 / 05期
关键词
FLASH radiotherapy; Silicon Carbide; dosimetry; beam monitoring; UHDR; ION RECOMBINATION; DOSIMETRY;
D O I
10.3390/app13052986
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ultra-high dose rate (UHDR) beams for FLASH radiotherapy present significant dosimetric challenges. Although novel approaches for decreasing or correcting ion recombination in ionization chambers are being proposed, applicability of ionimetric dosimetry to UHDR beams is still under investigation. Solid-state sensors have been recently investigated as a valuable alternative for real-time measurements, especially for relative dosimetry and beam monitoring. Among them, Silicon Carbide (SiC) represents a very promising candidate, compromising between the maturity of Silicon and the robustness of diamond. Its features allow for large area sensors and high electric fields, required to avoid ion recombination in UHDR beams. In this study, we present simulations and experimental measurements with the low energy UHDR electron beams accelerated with the ElectronFLASH machine developed by the SIT Sordina company (IT). The response of a newly developed 1 x 1 cm(2) SiC sensor in charge as a function of the dose-per-pulse and its radiation hardness up to a total delivered dose of 90 kGy, was investigated during a dedicated experimental campaign, which is, to our knowledge, the first characterization ever done of SiC with UHDR-pulsed beams accelerated by a dedicated ElectronFLASH LINAC. Results are encouraging and show a linear response of the SiC detector up to 2 Gy/pulse and a variation in the charge per pulse measured for a cumulative delivered dose of 90 kGy, within +/- 0.75%.
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页数:12
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