The Dual Function of RhoGDI2 in Immunity and Cancer

被引:3
|
作者
Tripathi, Mudrika [1 ]
Colige, Alain [1 ]
Deroanne, Christophe F. F. [1 ]
机构
[1] Univ Liege, Lab Connect Tissues Biol, GIGA Canc, B-4000 Liege, Belgium
关键词
RhoGDI2; 1; RhoGDI1; 2; Rho GTPases 3; cancer; 4; immunity; 5; GDP-DISSOCIATION INHIBITOR; LY-GDI; RHO-GTPASES; CELL-PROLIFERATION; BREAST-CANCER; EXPRESSION; INVASION; PROMOTES; MIGRATION; PROTEIN;
D O I
10.3390/ijms24044015
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases. It is highly expressed in hematopoietic cells but is also present in a large array of other cell types. RhoGDI2 has been implicated in multiple human cancers and immunity regulation, where it can display a dual role. Despite its involvement in various biological processes, we still do not have a clear understanding of its mechanistic functions. This review sheds a light on the dual opposite role of RhoGDI2 in cancer, highlights its underappreciated role in immunity and proposes ways to explain its intricate regulatory functions.
引用
收藏
页数:19
相关论文
共 50 条
  • [21] RhoGDI2 induced malignant phenotypes of pancreatic cancer cells via regulating Snail expression
    Yi, Bin
    Hu, You
    Zhu, Dongming
    Yao, Jun
    Zhou, Jian
    Zhang, Yi
    He, Zhilong
    Zhang, Lifeng
    Zhang, Zixiang
    Yang, Jian
    Tang, Yuchen
    Huang, Yujie
    Li, Dechun
    Liu, Qiuhua
    GENES & GENOMICS, 2022, 44 (05) : 561 - 569
  • [22] RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach cancer
    Koh, Sung A.
    Lee, Kyung Hee
    Choi, Eun Young
    Kim, Min Kyoung
    Jang, Byung Ik
    Lee, Si Hyung
    Kim, Kyeong Ok
    Kim, Kook Hyun
    Kim, Jae Ryong
    Kim, Sang Woon
    Kim, Se Won
    CANCER RESEARCH, 2014, 74 (19)
  • [23] Overexpression of RhoGDI2 correlates with the progression and prognosis of pancreatic carcinoma
    Yi, Bin
    Zhang, Yi
    Zhu, Dongming
    Zhang, Lifeng
    Song, Shiduo
    He, Songbing
    Zhang, Bing
    Li, Dechun
    Zhou, Jian
    ONCOLOGY REPORTS, 2015, 33 (03) : 1201 - 1206
  • [24] RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach cancer
    Sung Ae Koh
    Min Kyoung Kim
    Kyung Hee Lee
    Sang Woon Kim
    Jae-Ryong Kim
    Clinical & Experimental Metastasis, 2014, 31 : 805 - 815
  • [25] An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu)
    Song, Mia
    He, Qianjing
    Berk, Benjamin-Andreas
    Hartwig, John H.
    Stossel, Thomas P.
    Nakamura, Fumihiko
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 469 (03) : 659 - 664
  • [26] RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach cancer
    Koh, Sung Ae
    Kim, Min Kyoung
    Lee, Kyung Hee
    Kim, Sang Woon
    Kim, Jae-Ryong
    CLINICAL & EXPERIMENTAL METASTASIS, 2014, 31 (07) : 805 - 815
  • [27] Association of RhoGDI2 with HGF-mediated tumor invasion through VEGF in stomach cancer
    Koh, Sung Ae
    Lee, Kyung Hee
    Choi, Eun Young
    Kim, Min Kyoung
    Kim, Jae-Ryong
    Kim, Sang Woon
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [28] RhoGDI2 induced malignant phenotypes of pancreatic cancer cells via regulating Snail expression
    Bin Yi
    You Hu
    Dongming Zhu
    Jun Yao
    Jian Zhou
    Yi Zhang
    Zhilong He
    Lifeng Zhang
    Zixiang Zhang
    Jian Yang
    Yuchen Tang
    Yujie Huang
    Dechun Li
    Qiuhua Liu
    Genes & Genomics, 2022, 44 : 561 - 569
  • [29] RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells
    Cho, Hee Jun
    Park, Sun-Mi
    Kim, In-Kyu
    Nam, In-Koo
    Baek, Kyoung Eun
    Im, Min-Ju
    Yoo, Jong-Min
    Park, Seung-Ho
    Ryu, Ki-Jun
    Han, Hyun-Tak
    Kim, Hyo-Jin
    Hong, Soon-Chan
    Kim, Kwang Dong
    Pak, Yunbae
    Kim, Jae Won
    Lee, Chang Won
    Yoo, Jiyun
    ONCOTARGET, 2014, 5 (06) : 1554 - 1564
  • [30] The metastasis suppressor RhoGDI2 modulates tumor-host interactions
    Said, Neveen
    Owens, Charles
    Theodorescu, Dan
    CANCER RESEARCH, 2009, 69