The Dual Function of RhoGDI2 in Immunity and Cancer

被引：3
|
作者：
Tripathi, Mudrika [1 ]
Colige, Alain [1 ]
Deroanne, Christophe F. F. [1 ]
机构：
[1] Univ Liege, Lab Connect Tissues Biol, GIGA Canc, B-4000 Liege, Belgium
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期
关键词：
RhoGDI2; 1; RhoGDI1; 2; Rho GTPases 3; cancer; 4; immunity; 5; GDP-DISSOCIATION INHIBITOR; LY-GDI; RHO-GTPASES; CELL-PROLIFERATION; BREAST-CANCER; EXPRESSION; INVASION; PROMOTES; MIGRATION; PROTEIN;
D O I：
10.3390/ijms24044015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases. It is highly expressed in hematopoietic cells but is also present in a large array of other cell types. RhoGDI2 has been implicated in multiple human cancers and immunity regulation, where it can display a dual role. Despite its involvement in various biological processes, we still do not have a clear understanding of its mechanistic functions. This review sheds a light on the dual opposite role of RhoGDI2 in cancer, highlights its underappreciated role in immunity and proposes ways to explain its intricate regulatory functions.
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页数：19
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