A review on genetic alterations in CNS metastases related to breast cancer treatment. Is there a role for liquid biopsies in CSF?

被引：2

作者：

Wessels, Peter H. ^{[1
,2
]}

Boelens, Mirjam C. ^{[3
]}

Monkhorst, Kim ^{[3
]}

Sonke, Gabe S. ^{[4
]}

van den Broek, Daan ^{[5
]}

Brandsma, Dieta ^{[1
]}

机构：

[1] Netherlands Canc Inst, Dept Neurooncol, Amsterdam, Netherlands

[2] St Antonius Hosp, Dept Neurol, Nieuwegein, Utrecht, Netherlands

[3] Netherlands Canc Inst, Dept Pathol, Amsterdam, Netherlands

[4] Netherlands Canc Inst, Dept Med Oncol, Amsterdam, Netherlands

[5] Netherlands Canc Inst, Dept Lab Med, Amsterdam, Netherlands

来源：

JOURNAL OF NEURO-ONCOLOGY | 2023年 / 162卷 / 01期

关键词：

Breast cancer; Brain metastases; Leptomeningeal metastases; Liquid biopsy; Genetic alterations; Concordance; CENTRAL-NERVOUS-SYSTEM; BRAIN METASTASES; CEREBROSPINAL-FLUID; GENOMIC CHARACTERIZATION; TUMOR DNA; MUTATIONS; LANDSCAPE; EVOLUTION; PATHWAY;

D O I：

10.1007/s11060-023-04261-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acquired mutations or altered gene expression patterns in brain metastases (BM) and/or leptomeningeal metastases (LM) of breast cancer may play a role in therapy-resistance and offer new molecular targets and treatment options. Despite expanding knowledge of genetic alterations in breast cancer and their metastases, clinical applications for patients with central nervous system (CNS) metastases are currently limited. An emerging tool are DNA-techniques that may detect genetic alterations of the CNS metastases in the cerebrospinal fluid (CSF). In this review we discuss genetic studies in breast cancer and CNS metastases and the role of liquid biopsies in CSF.

引用

页码：1 / 13

页数：13

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