Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform

被引:29
作者
Choi, Anseo [1 ]
Javius-Jones, Kaila [2 ]
Hong, Seungpyo [2 ,3 ]
Park, Hansoo [1 ,3 ]
机构
[1] Chung Ang Univ, Sch Integrat Engn, Seoul, South Korea
[2] Univ Wisconsin, Sch Pharm, Pharmaceut Sci Div, Madison, WI USA
[3] Chung Ang Univ, Sch Integrat Engn, Seoul 06974, South Korea
来源
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2023年 / 18卷
基金
新加坡国家研究基金会;
关键词
drug delivery; homing ability; tumor microenvironment; drug loading; MESENCHYMAL STEM-CELLS; RED-BLOOD-CELLS; MEDIATED DELIVERY; NEUTROPHIL RECRUITMENT; IN-VITRO; CARRIER ERYTHROCYTES; MOUSE ERYTHROCYTES; TARGETED DELIVERY; ISCHEMIC-STROKE; CONTRAST AGENTS;
D O I
10.2147/IJN.S394389
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Nanoparticle-based drug delivery systems have been designed to treat various diseases. However, many problems remain, such as inadequate tumor targeting and poor therapeutic outcomes. To overcome these obstacles, cell-based drug delivery systems have been developed. Candidates for cell-mediated drug delivery include blood cells, immune cells, and stem cells with innate tumor tropism and low immunogenicity; they act as a disguise to deliver the therapeutic payload. In drug delivery systems, therapeutic agents are encapsulated intracellularly or attached to the surface of the plasma membrane and transported to the desired site. Here, we review the pros and cons of cell-based therapies and discuss their homing mechanisms in the tumor microenvironment. In addition, different strategies to load therapeutic agents inside or on the surface of circulating cells and the current applications for a wide range of disease treatments are summarized.
引用
收藏
页码:509 / 525
页数:17
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