One-Pot Three-Component Synthesis of Indolyl-4H-chromene-3-sulfonyl Fluoride: A Class of Important Pharmacophore

被引：8
|
作者：
Yin, Cheng-Lin [1 ,2 ]
Qin, Richard Zijian [1 ,2 ]
Qin, Hua-Li [1 ,2 ]
机构：
[1] Wuhan Univ Technol, State Key Lab Silicate Mat Architectures, Wuhan 430070, Hubei, Peoples R China
[2] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 05期
基金：
中国国家自然科学基金;
关键词：
ETHENESULFONYL FLUORIDE; SULFONYL FLUORIDES; SALICYLIC ALDEHYDES; CATALYZED REACTION; ANTICANCER AGENTS; DRUG DISCOVERY; SUFEX; INDOLE; ELECTROPHILES; CONSTRUCTION;
D O I：
10.1021/acs.joc.3c02706
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot, sequential three-component reaction between salicylaldehyde, indole, and 2-bromoprop-2-ene-1-sulfonyl fluoride (BPESF) has been demonstrated for the synthesis of sulfonyl fluoride substituted 4H-chromene derivatives in moderate to excellent yields (45%-94%). This one-pot sequential method features easily available starting materials, wide substrate scope, mild conditions, and great efficiency.
引用
收藏
页码：3618 / 3628
页数：11
相关论文
共 50 条
  • [41] One-Pot Three-Component Catalytic Enantioselective Synthesis of Homoallylboronates
    Ibrahem, Ismail
    Breistein, Palle
    Cordova, Armando
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (50) : 12036 - 12041
  • [42] Three-component one-pot reaction for the synthesis of β-amide ketones
    Yan-Ping Luo
    Qiong Chen
    Chemical Papers, 2013, 67 : 532 - 537
  • [43] One-Pot Three-Component Synthesis of Oxazine Derivatives in Water
    Rostami-Charati, Faramarz
    Hossaini, Zinatossadat
    Gharaee, Ebrahim
    Khalilzadeh, Mohammad A.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 : E174 - E177
  • [44] One-Pot, Three-Component Synthesis of 4H-Pyrans Using Cu(II) Oxymetasilicate
    Heravi, Majid M.
    Beheshtiha, Yahya S.
    Pirnia, Zahra
    Sadjadi, Samaheh
    Adibi, Mina
    SYNTHETIC COMMUNICATIONS, 2009, 39 (20) : 3663 - 3667
  • [45] One-Pot, Three-Component Coupling Approach to the Synthesis of α-Iminocarboxamides
    Masui, Hisashi
    Fuse, Shinichiro
    Takahashi, Takashi
    ORGANIC LETTERS, 2012, 14 (16) : 4090 - 4093
  • [46] Three-Component, One-Pot Synthesis of New Functionalized Pyrrolines
    Asghari, Sakineh
    Qandalee, Mohammad
    SYNTHETIC COMMUNICATIONS, 2010, 40 (14) : 2172 - 2177
  • [47] Fe3O4 magnetic nanoparticles coated with a copolymer: a novel reusable catalyst for one-pot three-component synthesis of 2-amino-4H-chromene
    Keshavarz, Mahdieh
    Abdoli-Senejani, Masumeh
    Hojati, Seyedeh Fatemeh
    Askari, Shivadokht
    REACTION KINETICS MECHANISMS AND CATALYSIS, 2018, 124 (02) : 757 - 766
  • [48] One-pot three-component synthesis of 2-substituted 4-aminoquinazolines
    Rad-Moghadam, Kurosh
    Samavi, Laleh
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 43 (04) : 913 - 916
  • [49] One-Pot, Three-Component Synthesis of Chiral 4-Alkylidene-2-oxazolidinones
    Kojima, Naoto
    Nishijima, Shogo
    Tanaka, Tetsuaki
    SYNLETT, 2009, (19) : 3171 - 3174
  • [50] Fe3O4 magnetic nanoparticles coated with a copolymer: a novel reusable catalyst for one-pot three-component synthesis of 2-amino-4H-chromene
    Mahdieh Keshavarz
    Masumeh Abdoli-Senejani
    Seyedeh Fatemeh Hojati
    Shivadokht Askari
    Reaction Kinetics, Mechanisms and Catalysis, 2018, 124 : 757 - 766
12345