One-Pot Three-Component Synthesis of Indolyl-4H-chromene-3-sulfonyl Fluoride: A Class of Important Pharmacophore

被引：8
|
作者：
Yin, Cheng-Lin [1 ,2 ]
Qin, Richard Zijian [1 ,2 ]
Qin, Hua-Li [1 ,2 ]
机构：
[1] Wuhan Univ Technol, State Key Lab Silicate Mat Architectures, Wuhan 430070, Hubei, Peoples R China
[2] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 05期
基金：
中国国家自然科学基金;
关键词：
ETHENESULFONYL FLUORIDE; SULFONYL FLUORIDES; SALICYLIC ALDEHYDES; CATALYZED REACTION; ANTICANCER AGENTS; DRUG DISCOVERY; SUFEX; INDOLE; ELECTROPHILES; CONSTRUCTION;
D O I：
10.1021/acs.joc.3c02706
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot, sequential three-component reaction between salicylaldehyde, indole, and 2-bromoprop-2-ene-1-sulfonyl fluoride (BPESF) has been demonstrated for the synthesis of sulfonyl fluoride substituted 4H-chromene derivatives in moderate to excellent yields (45%-94%). This one-pot sequential method features easily available starting materials, wide substrate scope, mild conditions, and great efficiency.
引用
收藏
页码：3618 / 3628
页数：11
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