Comparing a common clavicle maturation-based age estimation method to ordinary regression analyses with quadratic and sex-specific interaction terms in adolescents

被引:1
作者
Reder, Sebastian R. [1 ]
Fritzen, Isabel [2 ]
Brockmann, Marc A. [1 ]
Hardt, Jochen [3 ]
Elsner, Katrin [4 ]
Petrowski, Katja [3 ]
Bjelopavlovic, Monika [2 ]
机构
[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Neuroradiol, D-55131 Mainz, Germany
[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Prosthet Dent, Augustusplatz 2, D-55131 Mainz, Germany
[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med Psychol & Med Sociol, Duesbergweg 6, D-55131 Mainz, Germany
[4] Johannes Gutenberg Univ Mainz, Inst Legal Med, Univ Med Ctr, Pulverturm 9, D-55131 Mainz, Germany
关键词
BONE-MINERAL DENSITY; COMPUTED-TOMOGRAPHY; EPIPHYSEAL CARTILAGE; PREMATURE ADRENARCHE; MEDIAL CLAVICLE; RISK-FACTORS; OSSIFICATION; AROMATASE; GENDER; GROWTH;
D O I
10.1038/s41598-024-52980-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Established methods of age estimation are based on correlating defined maturation stages of bony structures with tables representing the observed range of biological ages in the majority of cases. In this retrospective monocentric study in southwestern Germany, common age estimation methodology was assessed in n = 198 subjects at the age of 25 or younger by analyzing the influence of age, quadratic age, biological sex and age-sex interaction on the ossification stages of the medial epiphysis fugue. Three readers (ICC >= 0.81 for left/right side) evaluated routine care computed tomography images of the clavicle with a slice thickness of 1 mm. By using least square regression analyses, to determine the real biological age a quadratic function was determined corrected for the age estimated by established methods and sex (R2 = 0.6 each side), reducing the mean absolute error and root mean squared error in the age estimation of women (2.57 and 3.19) and men (2.57 and 3.47) to 1.54 and 1.82 for women, and 1.54 and 2.25 for men. In women, the medial clavicle epiphysis seem to fuse faster, which was particularly observable from approximately 18 years of age. Before that age, the estimation method was relatively close to the ideal correlation between assessed and real age. To conclude, the presented new method enables more precise age estimation in individuals and facilitates the determination and quantification of additional variables, quantifying their influence on the maturation of the medial clavicle epiphysis based on the established ossification stages.
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共 79 条
[1]   Prevalence of hypospadias and other genital anomalies among singleton births, 1988-1997, in Scotland [J].
Ahmed, SF ;
Dobbie, R ;
Finlayson, AR ;
Gilbert, J ;
Youngson, G ;
Chalmers, J ;
Stone, D .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2004, 89 (02) :149-151
[2]   Sex determination using anthropometric dimensions of the clavicle in Iranian population [J].
Akhlaghi, Mitra ;
Moradi, Behzad ;
Hajibeygi, Marzieh .
JOURNAL OF FORENSIC AND LEGAL MEDICINE, 2012, 19 (07) :381-385
[3]   What you see may not be what you get: A brief, nontechnical introduction to overfitting in regression-type models [J].
Babyak, MA .
PSYCHOSOMATIC MEDICINE, 2004, 66 (03) :411-421
[4]   ISOLATED PRECOCIOUS PUBARCHE - AN APPROACH [J].
BALDUCCI, R ;
BOSCHERINI, B ;
MANGIANTINI, A ;
MORELLINI, M ;
TOSCANO, V .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (02) :582-589
[5]   Age estimation using CT imaging of the third molar tooth, the medial clavicular epiphysis, and the spheno-occipital synchondrosis: A multifactorial approach [J].
Bassed, Richard B. ;
Briggs, Christopher ;
Drummer, Olaf H. .
FORENSIC SCIENCE INTERNATIONAL, 2011, 212 (1-3) :273.e1-273.e5
[6]   Age estimation and the medial clavicular epiphysis: analysis of the age of majority in an Australian population using computed tomography [J].
Bassed, Richard B. ;
Drummer, Olaf H. ;
Briggs, Christopher ;
Valenzuela, Aurora .
FORENSIC SCIENCE MEDICINE AND PATHOLOGY, 2011, 7 (02) :148-154
[7]   Genetic and Clinical Spectrum of Aromatase Deficiency in Infancy, Childhood and Adolescence [J].
Belgorosky, A. ;
Guercio, G. ;
Pepe, C. ;
Saraco, N. ;
Rivarola, M. A. .
HORMONE RESEARCH, 2009, 72 (06) :321-330
[8]   Forensic Age Estimation: A Multifactorial Approach in a Retrospective Population Study [J].
Bjelopavlovic, Monika ;
Reder, Sebastian R. ;
Fritzen, Isabel ;
Brockmann, Marc A. ;
Hardt, Jochen ;
Petrowski, Katja .
DIAGNOSTICS, 2023, 13 (12)
[9]   Aromatase: Contributions to Physiology and Disease in Women and Men [J].
Blakemore, Jennifer ;
Naftolin, Fredrick .
PHYSIOLOGY, 2016, 31 (04) :258-269
[10]   CRITICAL YEARS AND STAGES OF PUBERTY FOR SPINAL AND FEMORAL BONE MASS ACCUMULATION DURING ADOLESCENCE [J].
BONJOUR, JP ;
THEINTZ, G ;
BUCHS, B ;
SLOSMAN, D ;
RIZZOLI, R .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (03) :555-563