Asymmetric Henry Reaction Using Cobalt Complexes with Bisoxazoline Ligands Bearing Two Fluorous Tags

被引：2

作者：

Ishihara, Kazuki ^{[1
]}

Kato, Yamato ^{[1
]}

Takeuchi, Narisa ^{[1
]}

Hayashi, Yuka ^{[1
]}

Hagiwara, Yuna ^{[1
]}

Shibuya, Shyota ^{[1
]}

Natsume, Tohya ^{[1
]}

Matsugi, Masato ^{[1
]}

机构：

[1] Meijo Univ, Fac Agr, 1-501 Shiogamaguchi,Tempaku Ku, Nagoya 4688502, Japan

来源：

MOLECULES | 2023年 / 28卷 / 22期

关键词：

fluorous; ligand; oxazoline; Henry reaction; absolute configuration; BIS(OXAZOLINE) LIGANDS; CATALYSTS; CYCLOPROPANATION; ALDOL;

D O I：

10.3390/molecules28227632

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of the presence of fluorous tags in bisoxazoline ligands on the stereoselectivity of the cobalt-catalyzed asymmetric Henry reaction was investigated. In contrast to the stereoselectivity obtained with conventional nonfluorous ligands, using bisoxazoline bidentate ligands featuring two fluorous tags in adjacent positions on the aromatic ring yielded a reversed stereoselectivity. The stereoselectivity also reversed when the fluorous tags were replaced with alkyl chains of equivalent length, albeit to a considerably lesser degree, highlighting the effect of the fluorous tags.

引用

页数：16

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