Influenza vaccination in Western Australian children: Exploring the health benefits and cost savings of increased vaccine coverage in children

被引：0

作者：

Blyth, Christopher C. ^{[1
,2
,3
,4
,11
]}

Fathima, Parveen ^{[1
,5
]}

Pavlos, Rebecca ^{[1
]}

Jacoby, Peter ^{[6
]}

Pavy, Olivia ^{[1
]}

Geelhoed, Elizabeth ^{[6
]}

Richmond, Peter C. ^{[1
,2
,7
,8
]}

Effler, Paul, V ^{[9
]}

Moore, Hannah C. ^{[1
,10
,12
]}

机构：

[1] Univ Western Australia, Telethon Kids Inst, Wesfarmers Ctr Vaccines & Infect Dis, Perth, WA, Australia

[2] Univ Western Australia, Sch Med, Perth, WA, Australia

[3] Perth Childrens Hosp, Dept Infect Dis, Perth, WA, Australia

[4] QEII Med Ctr, Dept Microbiol, PathWest Lab Med, Perth, WA, Australia

[5] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia

[6] Perth Childrens Hosp, Telethon Kids Inst, Perth, WA, Australia

[7] Perth Childrens Hosp, Dept Immunol, Perth, WA, Australia

[8] Perth Childrens Hosp, Dept Gen Paediat, Perth, WA, Australia

[9] Dept Hlth, Communicable Dis Control Directorate, Perth, WA, Australia

[10] Curtin Univ, Sch Populat Hlth, Perth, WA, Australia

[11] Perth Childrens Hosp, Hosp Ave, Nedlands, WA 6009, Australia

[12] Telethon Kids Inst, Hosp Ave, Nedlands, WA 6009, Australia

来源：

VACCINE: X | 2023年 / 15卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Influenza; Influenza vaccination; Costs; Child; IMMUNIZATION; IMPACT;

D O I：

10.1016/j.jvacx.2023.100399

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction: To assess potential benefits and direct healthcare cost savings with expansion of an existing childhood influenza immunisation program, we developed a dynamic transmission model for the state of Western Australia, evaluating increasing coverage in children < 5 years and routinely immunising school-aged children.Methods: A deterministic compartmental Susceptible-Exposed-Infectious-Recovered age-stratified transmission model was developed and calibrated using laboratory-notification and hospitalisation data. Base case vaccine coverage estimates were derived from 2019 data and tested under moderate, low and high vaccine effectiveness settings. The impact of increased coverage on the burden of influenza, influenza-associated presentations and net costs were assessed using the transmission model and estimated health utilisation costs.Results: Under base case vaccine coverage and moderate vaccine effectiveness settings, 225,460 influenza cases are expected annually across all ages. Direct healthcare costs of influenza were estimated to be A$27,608,286 per annum, dominated by hospital costs. Net cost savings of >$A1.5 million dollars were observed for every 10 % increase in vaccine coverage in children < 5 years. Additional benefits were observed by including primary school age children (5-11 years) in the funded influenza vaccination program - a reduction in cases, presentations, hospitalisations and approximately $A4 million net costs savings were observed for every 10 % increase in coverage. The further addition of older children (12-17 years) resulted in only moderate additional net cost savings figures, compared with a 5-11year-old program alone. Net costs savings were predominantly derived by a reduction in influenza-associated hospitalisation in adults.Conclusions: Any increase in influenza vaccine coverage in children < 5 years, above a base case of 50 % coverage resulted in a substantive reduction in influenza cases, presentations, hospitalisations and net costs when applied to the West Australian population. However, the most impactful pediatric program, from both a disease prevention and costs perspective, would be one that increased vaccination coverage among primary-school aged children.

引用

页数：9