Percutaneous Computed Tomography-Guided Oxygen-Ozone (O2O3) Injection Therapy in Patients with Lower Back Pain-An Interventional Two-Year Follow-Up Study of 321 Patients

被引：1

作者：

Davidovic, Kristina ^{[1
]}

Cotofana, Sebastian ^{[2
,3
,4
]}

Heisinger, Stephan ^{[5
]}

Savic, Slavica ^{[6
]}

Alfertshofer, Michael ^{[7
]}

Antonic, Tatjana ^{[1
]}

Jovanovic, Sanja ^{[8
]}

Ercegovac, Marko ^{[9
]}

Muto, Mario ^{[10
]}

Jeremic, Danilo ^{[11
]}

Janicijevic, Aleksandar ^{[12
]}

Rasulic, Lukas ^{[12
]}

Janosevic, Vesna ^{[12
]}

Saric, Lidija ^{[12
]}

Chua, Deborah ^{[13
]}

Masulovic, Dragan ^{[1
]}

Maksimovic, Ruzica ^{[1
]}

机构：

[1] Univ Clin Ctr Serbia, Ctr Radiol & Magnet Resonance Imaging, Belgrade 11000, Serbia

[2] Erasmus MC, Dept Dermatol, NL-3015 GD Rotterdam, Netherlands

[3] Queen Mary Univ London, Blizard Inst, Ctr Cutaneous Res, London E1 4NS, England

[4] Guangdong Second Prov Gen Hosp, Dept Plast & Reconstruct Surg, Guangzhou 510317, Peoples R China

[5] Med Univ Vienna, Dept Orthoped & Trauma Surg, A-1090 Vienna, Austria

[6] Univ Belgrade, Med Fac, Belgrade 11120, Serbia

[7] LMU Univ Hosp, Div Hand Plast & Aesthet Surg, D-80336 Munich, Germany

[8] Acibadem Bel Med, Belgrade 11000, Serbia

[9] Univ Clin Ctr Serbia, Clin Neurol, Belgrade 11000, Serbia

[10] Osped Cardarelli Napoli, Neuroradiol Dept, I-80131 Naples, Italy

[11] Inst Orthoped Surg Banjic, Belgrade 11000, Serbia

[12] Univ Clin Ctr Serbia, Clin Neurosurg, Belgrade 11000, Serbia

[13] MH Plast Surg, Singapore 238859, Singapore

来源：

DIAGNOSTICS | 2023年 / 13卷 / 21期

关键词：

low back pain; ozone; corticosteroids; magnet resonance imaging; computed tomographic imaging; lumbosacral spine; oxygen-ozone therapy; minimally invasive treatment; spine degeneration; HERNIATED LUMBAR DISC; SURGERY; CHEMONUCLEOLYSIS; METAANALYSIS; MANAGEMENT; SECONDARY; SCIATICA; DISEASE;

D O I：

10.3390/diagnostics13213370

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To assess the effect of oxygen-ozone therapy guided by percutaneous Computed Tomography (CT) compared to corticosteroids in individuals experiencing lower back pain (LBP) not attributed to underlying bone-related issues.Methods: A total of 321 patients (192 males and 129 females, mean age: 51.5 +/- 15.1 years) with LBP were assigned to three treatment groups: group A) oxygen-ozone only, group B) corticosteroids only, group C) oxygen-ozone and corticosteroids. Treatment was administered via CT-guided injections to the intervertebral disc (i.e., intradiscal location). Clinical improvement of pain and functionality was assessed via self-reported pain scales and magnetic resonance (MR) and CT imaging.Results: At all follow-up times, the mean score of the numeric rating scale and the total global pain scale (GPS) of study groups receiving oxygen-ozone (groups A and C) were statistically significantly lower than the study group receiving corticosteroids only (group B), with p < 0.001. There was a statistically significant difference between groups A and C at 30 days for the numeric rating scale.Conclusions: The percutaneous application of oxygen-ozone in patients with LBP due to degeneration of the lumbosacral spine showed long-lasting significant pain reduction of up to two years post-treatment when compared to corticosteroids alone. Combination therapy of oxygen-ozone and corticosteroids can be useful as corticosteroids showed statistically significant improvement in LBP earlier than the oxygen-ozone-only treatment.

引用

页数：14