Nanofibers in Organelles: From Structure Design to Biomedical Applications

被引:5
作者
Hu, Jing-Jing [1 ]
Lin, Niya [1 ]
Zhang, Yunfan [1 ]
Xia, Fan [1 ]
Lou, Xiaoding [1 ]
机构
[1] China Univ Geosci, State Key Lab Biogeol & Environm Geol, Engn Res Ctr Nanogeomat, Fac Mat Sci & Chem,Minist Educ, Wuhan 430074, Peoples R China
基金
中国国家自然科学基金;
关键词
Nanofiber; Organelle; Peptide; Self-Assembly; Tumor Therapy; SMALL MOLECULES; NANOPARTICLES; NANOMATERIALS; ASSEMBLIES; MORPHOLOGY; APOPTOSIS; ARREST;
D O I
10.1002/anie.202313139
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanofibers are one of the most important morphologies of molecular self-assemblies, the formation of which relies on the diverse intermolecular interactions of fibrous-forming units. In the past decade, rapid advances have been made in the biomedical application of nanofibers, such as bioimaging and tumor treatment. An important topic to be focused on is not only the nanofiber formation mechanism but also where it forms, because different destinations could have different influences on cells and its formation could be triggered by unique stimuli in organelles. It is therefore necessary and timely to summarize the nanofibers assembled in organelles. This minireview discusses the formation mechanism, triggering strategies, and biomedical applications of nanofibers, which may facilitate the rational design of nanofibers, improve our understanding of the relationship between nanofiber properties and organelle characteristics, allow a comprehensive recognition of organelles affected by materials, and enhance the therapeutic efficiency of nanofibers. Unique stimuli in organelles could trigger in situ self-assembly of nanofibers with ordered structures, thus exhibiting differential influences on cells. In this minireview, we feature nanofibers in organelles, highlight their formation mechanism and triggering strategies, and discuss the biomedical applications and current challenges.image
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页数:12
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