Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

被引:45
作者
Pusta, Alexandra [1 ,2 ]
Tertis, Mihaela [1 ]
Craciunescu, Izabell [3 ]
Turcu, Rodica [3 ]
Mirel, Simona [2 ]
Cristea, Cecilia [1 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Dept Analyt Chem & Instrumental Anal, 4 Louis Pasteur St, Cluj Napoca 400349, Romania
[2] Iuliu Hatieganu Univ Med & Pharm, Dept Med Devices, 4 Pasteur St, Cluj Napoca 400349, Romania
[3] Natl Inst Res & Dev Isotop & Mol Technol, Cluj Napoca 400293, Romania
关键词
magnetic nanomaterials; cancer; drug delivery systems; targeted therapy; personalized treatment; IRON-OXIDE NANOPARTICLES; CORE-SHELL NANOPARTICLES; IN-VITRO EVALUATION; SURFACE MODIFICATION; COLLOIDAL SPHERES; ANTICANCER DRUG; CANCER CELLS; MICRO-RNA; PARTICLES; CLUSTERS;
D O I
10.3390/pharmaceutics15071872
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
With the predicted rise in the incidence of cancer, there is an ever-growing need for new cancer treatment strategies. Recently, magnetic nanoparticles have stood out as promising nanostructures for imaging and drug delivery systems as they possess unique properties. Moreover, magnetic nanomaterials functionalized with other compounds can lead to multicomponent nanoparticles with innovative structures and synergetic performance. The incorporation of chemotherapeutic drugs or RNA in magnetic drug delivery systems represents a promising alternative that can increase efficiency and reduce the side effects of anticancer therapy. This review presents a critical overview of the recent literature concerning the advancements in the field of magnetic nanoparticles used in drug delivery, with a focus on their classification, characteristics, synthesis and functionalization methods, limitations, and examples of magnetic drug delivery systems incorporating chemotherapeutics or RNA.
引用
收藏
页数:37
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