Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

被引：43

作者：

Pusta, Alexandra ^{[1
,2
]}

Tertis, Mihaela ^{[1
]}

Craciunescu, Izabell ^{[3
]}

Turcu, Rodica ^{[3
]}

Mirel, Simona ^{[2
]}

Cristea, Cecilia ^{[1
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Dept Analyt Chem & Instrumental Anal, 4 Louis Pasteur St, Cluj Napoca 400349, Romania

[2] Iuliu Hatieganu Univ Med & Pharm, Dept Med Devices, 4 Pasteur St, Cluj Napoca 400349, Romania

[3] Natl Inst Res & Dev Isotop & Mol Technol, Cluj Napoca 400293, Romania

来源：

PHARMACEUTICS | 2023年 / 15卷 / 07期

关键词：

magnetic nanomaterials; cancer; drug delivery systems; targeted therapy; personalized treatment; IRON-OXIDE NANOPARTICLES; CORE-SHELL NANOPARTICLES; IN-VITRO EVALUATION; SURFACE MODIFICATION; COLLOIDAL SPHERES; ANTICANCER DRUG; CANCER CELLS; MICRO-RNA; PARTICLES; CLUSTERS;

D O I：

10.3390/pharmaceutics15071872

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With the predicted rise in the incidence of cancer, there is an ever-growing need for new cancer treatment strategies. Recently, magnetic nanoparticles have stood out as promising nanostructures for imaging and drug delivery systems as they possess unique properties. Moreover, magnetic nanomaterials functionalized with other compounds can lead to multicomponent nanoparticles with innovative structures and synergetic performance. The incorporation of chemotherapeutic drugs or RNA in magnetic drug delivery systems represents a promising alternative that can increase efficiency and reduce the side effects of anticancer therapy. This review presents a critical overview of the recent literature concerning the advancements in the field of magnetic nanoparticles used in drug delivery, with a focus on their classification, characteristics, synthesis and functionalization methods, limitations, and examples of magnetic drug delivery systems incorporating chemotherapeutics or RNA.

引用

页数：37

共 195 条

[1] Preparation and in-vitro evaluation of pH-responsive cationic cyclodextrin coated magnetic nanoparticles for delivery of methotrexate to the Saos-2 bone cancer cells [J].

Ahmadi, Delshad ;

Zarei, Mojtaba ;

Rahimi, Mahdi ;

Khazaie, Marzieh ;

Asemi, Zatollah ;

Mir, Seyed Mostafa ;

Sadeghpour, Alireza ;

Karimian, Ansar ;

Alemi, Fourogh ;

Rahmati-Yamchi, Mohammad ;

Salehi, Roya ;

Jadidi-Niaragh, Farhad ;

Yousefi, Mehdi ;

Khelgati, Nafiseh ;

Majidinia, Maryam ;

Safa, Amin ;

Yousefi, Bahman .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 57

[2] Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents [J].

Aires, Antonio ;

Fernandez-Afonso, Yilian ;

Guedes, Gabriela ;

Guisasola, Eduardo ;

Gutierrez, Lucia ;

Cortajarena, Aitziber L. .

CHEMISTRY OF MATERIALS, 2022, 34 (24) :10832-10841

[3] Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment [J].

Alpdemir, Sukran ;

Vural, Tayfun ;

Kara, Goknur ;

Bayram, Cem ;

Haberal, Erdem ;

Denkbas, Emir Baki .

IET NANOBIOTECHNOLOGY, 2020, 14 (07) :617-622

[4] Design and Invitro Characterization of Green Synthesized Magnetic Nanoparticles Conjugated with Multitargeted Poly Lactic Acid Copolymers for Co-delivery of siRNA and Paclitaxel [J].

Amani, Amin ;

Dustparast, Mohammad ;

Noruzpour, Mehran ;

Zakaria, Rasool Asghari ;

Ebrahimi, Hossein Ali .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 167

[5] Magnetic Functionalized Nanoparticles for Biomedical, Drug Delivery and Imaging Applications [J].

Anderson, Simon D. ;

Gwenin, Vanessa V. ;

Gwenin, Christopher D. .

NANOSCALE RESEARCH LETTERS, 2019, 14 (1)

[6] Recent progress of magnetic nanoparticles in biomedical applications: A review [J].

Anik, Muzahidul I. ;

Hossain, M. Khalid ;

Hossain, Imran ;

Mahfuz, A. M. U. B. ;

Rahman, M. Tayebur ;

Ahmed, Isteaque .

NANO SELECT, 2021, 2 (06) :1146-1186

[7]

Arrizabalaga J.H., 2022, Biomed. Eng. Adv, V3, DOI [DOI 10.1016/J.BEA.2022.100031, 10.1016/j.bea.2022.100031]

[8] Methotrexate anticancer drug delivery to breast cancer cell lines by iron oxide magnetic based nanocarrier [J].

Attari, Elahe ;

Nosrati, Hamed ;

Danafar, Hossein ;

Manjili, Hamidreza Kheiri .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2019, 107 (11) :2492-2500

[9] An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites [J].

Attia, Mohamed F. ;

Anton, Nicolas ;

Wallyn, Justine ;

Omran, Ziad ;

Vandamme, Thierry F. .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2019, 71 (08) :1185-1198

[10] Simple surface functionalization of magnetic nanoparticles with methotrexate-conjugated bovine serum albumin as a biocompatible drug delivery vehicle [J].

Azizi, Sedigheh ;

Nosrati, Hamed ;

Danafar, Hossein .

APPLIED ORGANOMETALLIC CHEMISTRY, 2020, 34 (04)

← 1 2 3 4 5 6 7 8 9 10 →