Outcomes for oligometastatic head and neck cancer treated with stereotactic body radiotherapy: Results from an international multi-institutional consortium

被引：4
作者：
Said, Badr Id [1 ]
Mutsaers, Adam [1 ]
Chen, Hanbo [1 ]
Husain, Zain A. [1 ]
Biswas, Tithi [2 ]
Dagan, Roi [3 ]
Erler, Darby [1 ]
Foote, Matthew [4 ]
Louie, Alexander V. [1 ]
Redmond, Kristin [5 ]
Ricardi, Umberto [6 ]
Sahgal, Arjun [1 ]
Poon, Ian [1 ,7 ]
机构：
[1] Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Dept Radiat Oncol, Toronto, ON, Canada
[2] Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH USA
[3] Univ Florida, Hlth Proton Therapy Inst, Jacksonville, FL USA
[4] Univ Queensland, Princess Alexandra Hosp, Dept Radiat Oncol, Brisbane, Qld, Australia
[5] Johns Hopkins Univ, Dept Radiat Oncol & Mol Radiat Sci, Sch Med, Baltimore, MD USA
[6] Univ Turin, Dept Oncol, Turin, Italy
[7] Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, 2075 Bayview Ave,T2 181, Toronto, ON M4N 3M5, Canada
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 10期
关键词：
oligometastatic; head and neck cancer; radiation oncology; SABR; SBRT; SQUAMOUS-CELL CARCINOMA; RADIATION-THERAPY; PULMONARY METASTASES; TRIAL; LUNG; MULTICENTER; RESECTION; ASTRO;
D O I：
10.1002/hed.27488
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundWe report the results of an international multi-institutional cohort of oligometastatic (OMD) head and neck cancer (HNC) patients treated with SBRT. MethodsPatients with OMD HNC (& LE;5 metastases) treated with SBRT between 2008 and 2016 at six institutions were included. Treated metastasis control (TMC), progression-free survival (PFS), and overall survival (OS) were analyzed by multivariable analysis (MVA). ResultsForty-two patients with 84 HNC oligometastases were analyzed. The TMC rate at 1 and 2 years were 80% and 66%, with a median time to recurrence of 10.1 months. The median PFS and OS were 4.7 and 23.3 months. MVA identified a PTV point maximum (BED)10 > 100 Gy as a predictor of improved TMC (HR = 0.31, p = 0.034), and a cumulative PTV > 48 cc as having worse PFS (HR = 2.99, p < 0.001). ConclusionFavorable TMC and OS was observed in OMD HNCs treated with SBRT.
引用
收藏
页码：2627 / 2637
页数：11
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