Exposure to pyrogallol impacts the hemato-biochemical endpoints in catfish (Clarias gariepinus)*

被引:16
|
作者
Hamed, Mohamed [1 ]
Martyniuk, Christopher J. [2 ]
Said, Rashad E. M. [1 ]
Soliman, Hamdy A. M. [3 ]
Badrey, Ahmed E. A. [1 ]
Hassan, Elhagag A. [4 ]
Abdelhamid, Hani N. [5 ,6 ]
Osman, Alaa G. M. [1 ]
Sayed, Alaa El -Din H. [7 ,8 ]
机构
[1] Al Azhar Univ, Fac Sci, Dept Zool, Assiut Branch, Assiut 71524, Egypt
[2] Univ Florida, Coll Vet Med, Ctr Environm & Human Toxicol, Dept Physiol Sci, Gainesville, FL 32611 USA
[3] Sohag Univ, Fac Sci, Dept Zool, Sohag 8562, Egypt
[4] Assiut Univ, Fac Sci, Dept Bot & Microbiol, Assiut 71516, Egypt
[5] Assiut Univ, Dept Chem, Adv Multifunct Mat Lab, Assiut 71515, Egypt
[6] British Univ Egypt, Nanotechnol Res Ctr NTRC, Suez Desert Rd,POB 43, Cairo 11837, Egypt
[7] Assiut Univ, Fac Sci, Dept Zool, Assiut 71516, Egypt
[8] Assiut Univ, Mol Biol Res & Studies Inst, Assiut 71516, Egypt
关键词
Pyrogallol; Hematological; Biochemical; Electrolyte balance; Erythron profile; FRESH-WATER FISH; OXIDATIVE STRESS; INDUCED HEPATOTOXICITY; CLARIAS-GARIEPINUS; SPIRULINA-PLATENSIS; PROTECTIVE ROLE; ACUTE TOXICITY; LABEO-ROHITA; TANNIC-ACID; BLOOD-CELLS;
D O I
10.1016/j.envpol.2023.122074
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Pyrogallol is widely used in several industrial applications and can subsequently contaminate aquatic ecosystems. Here, we report for the first time the presence of pyrogallol in wastewater in Egypt. Currently, there is a complete lack of toxicity and carcinogenicity data for pyrogallol exposure in fish. To address this gap, both acute and sub-acute toxicity experiments were conducted to determine the toxicity of pyrogallol in catfish (Clarias gariepinus). Behavioral and morphological endpoints were evaluated, in addition to blood hematological endpoints, biochemical indices, electrolyte balance, and the erythron profile (poikilocytosis and nuclear abnormalities). In the acute toxicity assay, it was determined that the 96 h median-lethal concentration (96 h-LC50) of pyrogallol for catfish was 40 mg/L. In sub-acute toxicity experiment, fish divided into four groups; Group 1 was the control group. Group 2 was exposed to 1 mg/L of pyrogallol, Group 3 was exposed to 5 mg/L of pyrogallol, and Group 4 was exposed to 10 mg/L of pyrogallol. Fish showed morphological changes such as erosion of the dorsal and caudal fins, skin ulcers, and discoloration following exposure to pyrogallol for 96 h. Exposure to 1, 5, or 10 mg/L pyrogallol caused a significant decrease in hematological indices, including red blood cells (RBCs), hemoglobin, hematocrit, white blood cells (WBC), thrombocytes, and large and small lymphocytes in a dosedependent manner. Several biochemical parameters (creatinine, uric acid, liver enzymes, lactate dehydrogenase, and glucose) were altered in a concentration dependent manner with short term exposures to pyrogallol. Pyrogallol exposure also caused a significant concentration-dependent rise in the percentage of poikilocytosis and nuclear abnormalities of RBCs in catfish. In conclusion, our data suggest that pyrogallol should be considered further in environmental risk assessments of aquatic species.
引用
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页数:12
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