Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies

被引：14
作者：
Jia, Wenhui [1 ,2 ,3 ,4 ]
Huang, Zhao [1 ,2 ,3 ,4 ]
Zhou, Li [5 ]
Liou, Yih-Cherng [6 ,7 ]
Di Virgilio, Francesco [8 ]
Ulrich, Henning [9 ,10 ]
Illes, Peter [9 ,11 ]
Zhang, Wei [12 ,13 ,14 ]
Huang, Canhua [1 ,2 ,3 ,4 ,15 ]
Tang, Yong [9 ,16 ,17 ]
机构：
[1] West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Peoples R China
[2] West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China
[4] Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China
[5] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400016, Peoples R China
[6] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 117573, Singapore
[7] Natl Univ Singapore, Fac Sci, Dept Biol Sci, 14 Sci Dr 4, Singapore 117573, Singapore
[8] Univ Ferrara, Dept Med Sci, Ferrara, Italy
[9] Chengdu Univ Tradit Chinese Med, Int Joint Res Ctr Purinerg Signalling, Chengdu 610075, Peoples R China
[10] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo, Brazil
[11] Univ Leipzig, Rudolf Boehm Inst Pharmakol & Toxikol, Leipzig, Germany
[12] Sichuan Univ, Mental Hlth Ctr, Chengdu 610041, Peoples R China
[13] Sichuan Univ, West China Hosp, Psychiat Lab, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[14] Sichuan Univ, West China Hosp, West China Biomed Big Data Ctr, Chengdu 610041, Peoples R China
[15] Chengdu Univ Tradit Chinese Med, Inst TCM Based Stress Med, Chengdu 611137, Peoples R China
[16] Chengdu Univ Tradit Chinese Med, Sch Hlth & Rehabil, Chengdu 610075, Peoples R China
[17] Chengdu Univ Tradit Chinese Med, Acupuncture & Chronobiol Key Lab Sichuan Prov, Chengdu 610075, Peoples R China
来源：
DRUG RESISTANCE UPDATES | 2023年 / 70卷
基金：
巴西圣保罗研究基金会;
关键词：
Purinergic signalling; Cancer; Therapeutic resistance; Targeted therapy; RECEPTOR ANTAGONIST; EXTRACELLULAR ATP; DELIVERY-SYSTEMS; IN-VIVO; CELLS; IMMUNOSUPPRESSION; MICROENVIRONMENT; EXPRESSION; CARCINOMA; MIGRATION;
D O I：
10.1016/j.drup.2023.100988
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Purinergic signalling, consisting of extracellular purines and purinergic receptors, modulates cell proliferation, invasion and immunological reaction during cancer progression. Here, we focus on current evidence that suggests the crucial role of purinergic signalling in mediating cancer therapeutic resistance, the major obstacle in cancer treatment. Mechanistically, purinergic signalling can modulate the tumor microenvironment (TME), epithelial-mesenchymal transition (EMT) and anti-tumor immunity, thus affecting drug sensitivity of tumor cells. Currently, some agents attempting to target purinergic signalling either in tumor cells or in tumor-associated immune cells are under preclinical or clinical investigation. Moreover, nano-based delivery technologies significantly improve the efficacy of agents targeting purinergic signalling. In this review article, we summarize the mechanisms of purinergic signalling in promoting cancer therapeutic resistance and discuss the potentials and challenges of targeting purinergic signalling in future cancer treatment.
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页数：13
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