Implications from proteomic studies investigating circadian rhythm disorder-regulated neurodegenerative disease pathology

被引：3

作者：

Liu, Weiwei ^{[1
]}

Ma, Ruze ^{[1
,2
]}

Sun, Chen ^{[1
,3
]}

Xu, Yingxi ^{[1
]}

Liu, Yang ^{[1
]}

Hu, Jiajin ^{[1
]}

Ma, Yanan ^{[1
,4
]}

Wang, Difei ^{[2
]}

Wen, Deliang ^{[1
]}

Yu, Yang ^{[1
]}

机构：

[1] China Med Univ, Hlth Sci Inst, Key Lab Obes & Glucose, Lipid Associated Metab Dis, Shenyang 110122, Liaoning, Peoples R China

[2] China Med Univ, Dept Gerontol, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China

[3] China Med Univ, Dept Radiol, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China

[4] China Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Shenyang 110122, Liaoning, Peoples R China

来源：

SLEEP MEDICINE REVIEWS | 2023年 / 70卷

基金：

中国国家自然科学基金;

关键词：

Circadian rhythm disorder; Neurodegenerative diseases; Sleep disruption; Biomarker; Proteomics; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; GENE-EXPRESSION; CLOCK; SLEEP; HIPPOCAMPUS; BRAIN; CELLS; DYSFUNCTION; MODULATION;

D O I：

10.1016/j.smrv.2023.101789

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neurodegenerative diseases (NDs) affect 15% of the world's population and are becoming an increasingly common cause of morbidity and mortality worldwide. Circadian rhythm disorders (CRDs) have been reported to be involved in the pathogenic regulation of various neurologic diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis. Proteomic technology is helpful to explore treatment targets for CRDs in patients with NDs. Here, we review the key differentially expressed (DE) proteins identified in previous proteomic studies investigating NDs, CRDs and associated models and the related pathways identified by enrichment analysis. Furthermore, we summarize the advantages and disadvantages of the above studies and propose new proteomic technologies for the precise study of circadian disorder-mediated regulation of ND pathology. This review provides a theoretical and technical reference for the precise study of circadian disorder-mediated regulation of ND pathology.

引用

页数：15

共 98 条

[61] Circadian Chimeric Mice Reveal an Interplay Between the Suprachiasmatic Nucleus and Local Brain Clocks in the Control of Sleep and Memory [J].