Diverse heterochromatin states restricting cell identity and reprogramming

被引：19

作者：

McCarthy, Ryan L. ^{[1
]}

Zhang, Jingchao ^{[1
]}

Zaret, Kenneth S. ^{[1
]}

机构：

[1] Univ Penn, Inst Regenerat Med, Penn Epigenet Inst, Perelman Sch Med,Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2023年 / 48卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TRANSPOSABLE ELEMENTS; TRANSCRIPTION FACTORS; H3K9; METHYLATION; GENE-EXPRESSION; FIBROBLASTS; DNA; GENOME; FERTILIZATION; ARCHITECTURE; CONTROLLERS;

D O I：

10.1016/j.tibs.2023.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heterochromatin is defined as a chromosomal domain harboring repressive H3K9me2/3 or H3K27me3 histone modifications and relevant factors that physically compact the chromatin. Heterochromatin can restrict where transcription factors bind, providing a barrier to gene activation and changes in cell identity. While heterochromatin thus helps maintain cell differentiation, it presents a barrier to overcome during efforts to reprogram cells for biomedical purposes. Recent findings have revealed complexity in the composition and regulation of heterochromatin, and shown that transiently disrupting the machinery of heterochromatin can enhance reprogramming. Here, we discuss how heterochromatin is established and maintained during development, and how our growing understanding of the mechanisms regulating H3K9me3 heterochromatin can be leveraged to improve our ability to direct changes in cell identity.

引用

页码：513 / 526

页数：14

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