Modulation of neuronal excitability by binge alcohol drinking

被引：4

作者：

Gimenez-Gomez, Pablo ^{[1
,2
]}

Le, Timmy ^{[1
,2
,3
]}

Martin, Gilles E. ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Dept Neurobiol, Chan Med Sch, Worcester, MA 01655 USA

[2] Brudnick Neuropsychiat Res Inst, Worcester, MA 01655 USA

[3] UMass Chan Med Sch, Morningside Grad Sch Biomed Sci, Grad Program Neurosci, Worcester, MA USA

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2023年 / 16卷

关键词：

alcohol; binge alcohol drinking; neuroadaptation; neuronal excitability; ion channel; CHRONIC INTERMITTENT ETHANOL; NUCLEUS-ACCUMBENS NEURONS; RECEPTOR-MEDIATED NEUROTRANSMISSION; ORBITOFRONTAL CORTEX NEURONS; SENSITIVE GLYCINE RECEPTORS; CA2+-ACTIVATED K+ CHANNELS; TONICALLY ACTIVE NEURONS; GENE-EXPRESSION CHANGES; LONG-TERM POTENTIATION; YOUNG SOCIAL DRINKERS;

D O I：

10.3389/fnmol.2023.1098211

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Drug use poses a serious threat to health systems throughout the world. The number of consumers rises every year being alcohol the drug of abuse most consumed causing 3 million deaths (5.3% of all deaths) worldwide and 132.6 million disability-adjusted life years. In this review, we present an up-to-date summary about what is known regarding the global impact of binge alcohol drinking on brains and how it affects the development of cognitive functions, as well as the various preclinical models used to probe its effects on the neurobiology of the brain. This will be followed by a detailed report on the state of our current knowledge of the molecular and cellular mechanisms underlying the effects of binge drinking on neuronal excitability and synaptic plasticity, with an emphasis on brain regions of the meso-cortico limbic neurocircuitry.

引用

页数：16

共 292 条

[91] LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites [J].