SARS-CoV-2 Antibody Dynamics in Healthcare Workers after mRNA Vaccination

被引:4
|
作者
Dieckhaus, Kevin D. [1 ]
Kim, Min-Jung [1 ]
Shen, Jian-Bing [1 ]
Liang, Tina S. [1 ]
Kleinberg, Michael J. [1 ]
Siedlarz, Kristen M. [1 ]
Banach, David B. [1 ]
Metersky, Mark L. [1 ]
Fuller, Rob P. [1 ]
Mortensen, Eric M. [1 ]
Liang, Bruce T. [1 ]
机构
[1] UConn Hlth, Farmington, CT 06030 USA
关键词
SARS-CoV-2; COVID-19; neutralizing antibody; bnt162b2; mRNA-1273; healthcare workers; COVID-19; VACCINE; INFECTION; 2ND;
D O I
10.3390/vaccines11020358
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Since the emergence of SARS-CoV-2, maintaining healthcare worker (HCW) health and safety has been fundamental to responding to the global pandemic. Vaccination with mRNA-base vaccines targeting SARS-CoV-2 spike protein has emerged as a key strategy in reducing HCW susceptibility to SARS-CoV-2, however, neutralizing antibody responses subside with time and may be influenced by many variables. We sought to understand the dynamics between vaccine products, prior clinical illness from SARS-CoV-2, and incidence of vaccine-associated adverse reactions on antibody decay over time in HCWs at a university medical center. A cohort of 296 HCWs received standard two-dose vaccination with either bnt162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) and were evaluated after two, six, and nine months. Subjects were grouped by antibody decay curve into steep antibody decliners gentle decliners. Vaccination with mRNA-1273 led to more sustained antibody responses compared to bnt162b2. Subjects experiencing vaccine-associated symptoms were more likely to experience a more prolonged neutralizing antibody response. Subjects with clinical SARS-CoV-2 infection prior to vaccination were more likely to experience vaccination-associated symptoms after first vaccination and were more likely to have a more blunted antibody decay. Understanding factors associated with vaccine efficacy may assist clinicians in determining appropriate vaccine strategies in HCWs.
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页数:14
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