Simultaneous Spectral Temporal Modelling for a Time-Resolved Fluorescence Emission Spectrum

被引：1
作者：
Adams, Alexandra C. [1 ]
Kufcsak, Andras [1 ]
Ehrlich, Katjana [3 ]
Dhaliwal, Kevin [1 ]
Seth, Sohan [1 ,2 ,3 ]
机构：
[1] Univ Edinburgh, Queens Med Res Inst, Ctr Inflammat Res, Translat Healthcare Technol Grp, Edinburgh EH16 4TJ, Scotland
[2] Univ Edinburgh, Sch Informat, Edinburgh EH16 4TJ, Scotland
[3] Heriot Watt Univ, Scottish Univ Phys Alliance SUPA, Edinburgh EH16 4TJ, Scotland
来源：
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2023年 / 70卷 / 08期
基金：
英国医学研究理事会;
关键词：
Fluorescence lifetime; time-resolved fluor-escence spectroscopy; B-splines; non-linear least squares; OF-MASS METHOD; LIFETIME STANDARDS; SPECTROSCOPY; YIELDS; DECAY;
D O I：
10.1109/TBME.2023.3244664
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Innovations in complementary metal-oxide semiconductor (CMOS) single-photon avalanche diode (SPAD) technology has featured in the development of next-generation instruments for point-based time-resolved fluorescence spectroscopy (TRFS). These instruments provide hundreds of spectral channels, allowing the collection of fluorescence intensity and fluorescence lifetime information over a broad spectral range at a high spectral and temporal resolution. We present Multichannel Fluorescence Lifetime Estimation, MuFLE, an efficient computational approach to exploit the unique multi-channel spectroscopy data with an emphasis on simultaneous estimation of the emission spectra, and the respective spectral fluorescence lifetimes. In addition, we show that this approach can estimate the individual spectral characteristics of fluorophores from a mixed sample.
引用
收藏
页码：2395 / 2403
页数：9
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