The Genes-Stemness-Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints

被引：2
作者：
Stella, Giulia M. [1 ,2 ]
Marchio, Caterina [3 ,4 ]
Bari, Elia [5 ]
Ferrarotti, Ilaria [1 ,2 ]
Bertuccio, Francesco R. [1 ,2 ]
Di Gennaro, Antonella [2 ]
Abbott, David Michael [6 ]
Putignano, Paola [1 ,2 ]
Campo, Ilaria [2 ]
Torre, Maria Luisa [5 ]
Corsico, Angelo G. [1 ,2 ]
机构：
[1] Univ Pavia, Dept Internal Med & Med Therapeut, Med Sch, I-27100 Pavia, Italy
[2] IRCCS Policlin San Matteo, Cardiothorac & Vasc Dept, Unit Resp Dis, I-27100 Pavia, Italy
[3] Univ Turin, Dept Med Sci, I-10124 Turin, Italy
[4] FPO IRCCS Candiolo Canc Inst, Pathol Unit, Str Provinciale 142, I-10060 Candiolo, Italy
[5] Univ Piemonte Orientale, Dept Pharmaceut Sci, Largo Donegani 2-3, I-28100 Novara, Italy
[6] Univ Pavia, Dept Surg Pediat & Diagnost Sci, I-27100 Pavia, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期
关键词：
malignant pleural mesothelioma; genetics; microenvironment; targeted therapies; EXTRACELLULAR VESICLES; CELL NICHE; PROTEOMIC ANALYSIS; DNA-REPAIR; CANCER; HYPOXIA; EXPRESSION; EXOSOMES; CLASSIFICATION; IDENTIFICATION;
D O I：
10.3390/ijms24043496
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from the exceptional crosstalk between neoplastic cells and matrix components, among which one main area of focus is hypoxia. Here we discuss the novel therapeutic strategies focused on the exploitation of MPM genetic asset and its interconnection with the surrounding hypoxic microenvironment as well as transcript products and microvesicles representing both an insight into the pathogenesis and promising actionable targets.
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页数：21
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