Hypoxia-mediated activation of hypoxia-inducible factor-1α in triple-negative breast cancer: A review

被引：5

作者：

Liu, Lihui ^{[1
,2
]}

Bai, Jie ^{[2
]}

Hu, Lanxin ^{[3
]}

Jiang, Daqing ^{[2
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Shenyang, Peoples R China

[2] Dalian Univ Technol, China Med Univ, Liaoning Canc Hosp Inst, Dept Breast Surg,Canc Hosp, Shenyang 110801, Peoples R China

[3] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Luzhou, Peoples R China

来源：

MEDICINE | 2023年 / 102卷 / 43期

关键词：

HIF-1; alpha; hypoxia; signaling pathways; TNBC; HIF-1-ALPHA; PATHWAY; PROTEIN; SITES; CELLS; STAT3; DNA;

D O I：

10.1097/MD.0000000000035493

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Triple-negative breast cancer (TNBC) is a subtype of breast cancer (BC) that is highly aggressive and hypoxic compared with other subtypes. The role of hypoxia-inducible factor 1 alpha (HIF-1 alpha) as a key hypoxic transcription factor in oncogenic processes has been extensively studied. Recently, it has been shown that HIF-1 alpha regulates the complex biological processes of TNBC, such as glycolysis, angiogenesis, invasion and metastasis, BC stem cells enrichment, and immune escape, to promote TNBC survival and development through the activation of downstream target genes. This article discusses the expression of the HIF-1 alpha transcription factor in TNBC and the Hypoxia-mediated activation of hypoxia-inducible factor-1 alpha in triple-negative BC. It offers a fresh approach to clinical research and treatment for TNBC.

引用

页数：7

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