Immunometabolism and immune response regulate macrophage function in atherosclerosis

被引：38

作者：

Xue, Sheng ^{[1
]}

Su, Zhe ^{[1
]}

Liu, Dacheng ^{[1
]}

机构：

[1] Qingdao Univ, Affiliated Hosp, Inst Translat Med, Coll Med, Qingdao 266003, Peoples R China

来源：

AGEING RESEARCH REVIEWS | 2023年 / 90卷

关键词：

Atherosclerosis; Macrophage; Immunometabolism; Oxidation-specific epitopes; Immune response; LOW-DENSITY-LIPOPROTEIN; OXIDATION-SPECIFIC EPITOPES; FOAM CELL-FORMATION; TOLL-LIKE RECEPTORS; PATTERN-RECOGNITION RECEPTORS; HYPOXIA-INDUCIBLE FACTOR; CHOLESTEROL EFFLUX; NATURAL ANTIBODIES; MONOCLONAL AUTOANTIBODIES; OXIDIZED PHOSPHOLIPIDS;

D O I：

10.1016/j.arr.2023.101993

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macrophages are crucial in the progression of atherosclerotic cardiovascular disease (ASCVD). In the atherosclerotic lesions, macrophages play a central role in maintaining inflammatory response, promoting plaque development, and facilitating thrombosis. Increasing studies indicate that metabolic reprogramming and immune response mediate macrophage functional changes in all stages of atherosclerosis. In this review article, we explain how metabolic changes in glycolysis, oxidative phosphorylation, the tricarboxylic acid cycle, fatty acid synthesis, fatty acid oxidation, and cholesterol metabolism regulate macrophage function in atherosclerosis. We discuss how immune response to oxidized lipids regulate macrophage function in atherosclerosis. Additionally, we explore how abnormal metabolism leads to macrophage mitochondrial dysfunction in atherosclerosis.

引用

页数：11

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