Role of interleukins in acute myeloid leukemia

被引：5
作者：
Wang, Yin [1 ]
Tang, Xiao [1 ]
Zhu, Yu [1 ]
Yang, Xiao-xiao [1 ]
Liu, Bei [1 ,2 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China
[2] Lanzhou Univ, Affiliated Hosp 1, Dept Hematol, 1 Donggang West Rd, Lanzhou, Peoples R China
来源：
LEUKEMIA & LYMPHOMA | 2023年 / 64卷 / 08期
关键词：
Acute myeloid leukemia; interleukin; cytokine; tumor microenvironment; immunity; STEM-CELL TRANSPLANTATION; REGULATORY T-CELLS; QUALITY-OF-LIFE; LOW-DOSE IL-2; CYTOKINE LEVELS; GROWTH-FACTOR; BETA-CATENIN; GM-CSF; EXPRESSION; PROLIFERATION;
D O I：
10.1080/10428194.2023.2218508
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acute myeloid leukemia (AML) is a hematological malignancy with strong heterogeneity. Immune disorders are a feature of various malignancies, including AML. Interleukins (ILs) and other cytokines participate in a series of biological processes of immune disorders in the microenvironment, and serve as a bridge for communication between various cellular components in the immune system. The role of ILs in AML is complex and pleiotropic. It can not only play an anti-AML role by enhancing anti-leukemia immunity and directly inducing AML cell apoptosis, but also promote the growth, proliferation and drug resistance of AML. These properties of ILs can be used to explore their potential efficacy in disease monitoring, prognosis assessment, and development of new treatment strategies for AML. This review aims to clarify some of the complex roles of ILs in AML and their clinical applications.
引用
收藏
页码：1400 / 1413
页数：14
相关论文
共 141 条
[21]   Lenalidomide Combined with Interferon α-1b and Interleukin-2 in the Treatment of 21 Cases of Acute Myeloid Leukemia [J].
Cheng, Cheng ;
Mi, Ruihua ;
Li, Dongbei ;
Chen, Lin ;
Wei, Xudong .
TURKISH JOURNAL OF HEMATOLOGY, 2021, 38 (03) :230-232
[22]   CXCL8 derived from mesenchymal stromal cells supports survival and proliferation of acute myeloid leukemia cells through the PI3K/AKT pathway [J].
Cheng, Jingying ;
Li, Ying ;
Liu, Shiqi ;
Jiang, Yajing ;
Ma, Jiao ;
Wan, Li ;
Li, Qinghua ;
Pang, Tianxiang .
FASEB JOURNAL, 2019, 33 (04) :4755-4764
[23]   CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8+ T Cells by Inhibiting mTOR Pathways [J].
Choi, Young Joon ;
Lee, Hoyoung ;
Kim, Jong Hoon ;
Kim, So-Young ;
Koh, June-Young ;
Sa, Moa ;
Park, Su-Hyung ;
Shin, Eui-Cheol .
JOURNAL OF IMMUNOLOGY, 2022, 209 (06) :1108-1117
[24]   First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia [J].
Cooley, Sarah ;
He, Fiona ;
Bachanova, Veronika ;
Vercellotti, Gregory M. ;
DeFor, Todd E. ;
Curtsinger, Julie M. ;
Robertson, Paul ;
Grzywacz, Bartosz ;
Conlon, Kevin C. ;
Waldmann, Thomas A. ;
McKenna, David H. ;
Blazar, Bruce R. ;
Weisdorf, Daniel J. ;
Miller, Jeffrey S. .
BLOOD ADVANCES, 2019, 3 (13) :1970-1980
[25]   Neutrophils as regulators of the hematopoietic niche [J].
Cossio, Itziar ;
Lucas, Daniel ;
Hidalgo, Andres .
BLOOD, 2019, 133 (20) :2140-2148
[26]   INTERLEUKIN-1 AS AN AUTOCRINE GROWTH-FACTOR FOR ACUTE MYELOID-LEUKEMIA CELLS [J].
COZZOLINO, F ;
RUBARTELLI, A ;
ALDINUCCI, D ;
SITIA, R ;
TORCIA, M ;
SHAW, A ;
DIGUGLIELMO, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2369-2373
[27]   The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance [J].
David, Justin M. ;
Dominguez, Charli ;
Hamilton, Duane H. ;
Palena, Claudia .
VACCINES, 2016, 4 (03)
[28]   GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation [J].
Dougan, Michael ;
Dranoff, Glenn ;
Dougan, Stephanie K. .
IMMUNITY, 2019, 50 (04) :796-811
[29]   The IL-4, IL-13 and IL-31 pathways in atopic dermatitis [J].
Dubin, Celina ;
Del Duca, Ester ;
Guttman-Yassky, Emma .
EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2021, 17 (08) :835-852
[30]   Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP [J].
Fabbi, Marina ;
Carbotti, Grazia ;
Ferrini, Silvano .
JOURNAL OF LEUKOCYTE BIOLOGY, 2015, 97 (04) :665-675
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