Role of interleukins in acute myeloid leukemia

被引：5
作者：
Wang, Yin [1 ]
Tang, Xiao [1 ]
Zhu, Yu [1 ]
Yang, Xiao-xiao [1 ]
Liu, Bei [1 ,2 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China
[2] Lanzhou Univ, Affiliated Hosp 1, Dept Hematol, 1 Donggang West Rd, Lanzhou, Peoples R China
来源：
LEUKEMIA & LYMPHOMA | 2023年 / 64卷 / 08期
关键词：
Acute myeloid leukemia; interleukin; cytokine; tumor microenvironment; immunity; STEM-CELL TRANSPLANTATION; REGULATORY T-CELLS; QUALITY-OF-LIFE; LOW-DOSE IL-2; CYTOKINE LEVELS; GROWTH-FACTOR; BETA-CATENIN; GM-CSF; EXPRESSION; PROLIFERATION;
D O I：
10.1080/10428194.2023.2218508
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acute myeloid leukemia (AML) is a hematological malignancy with strong heterogeneity. Immune disorders are a feature of various malignancies, including AML. Interleukins (ILs) and other cytokines participate in a series of biological processes of immune disorders in the microenvironment, and serve as a bridge for communication between various cellular components in the immune system. The role of ILs in AML is complex and pleiotropic. It can not only play an anti-AML role by enhancing anti-leukemia immunity and directly inducing AML cell apoptosis, but also promote the growth, proliferation and drug resistance of AML. These properties of ILs can be used to explore their potential efficacy in disease monitoring, prognosis assessment, and development of new treatment strategies for AML. This review aims to clarify some of the complex roles of ILs in AML and their clinical applications.
引用
收藏
页码：1400 / 1413
页数：14
相关论文
共 141 条
[1]   Revisiting IL-2: Biology and therapeutic prospects [J].
Abbas, Abul K. ;
Trotta, Eleonora ;
Simeonov, Dimitre R. ;
Marson, Alexander ;
Bluestone, Jeffrey A. .
SCIENCE IMMUNOLOGY, 2018, 3 (25)
[2]   MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia [J].
Abdul-Aziz, Amina M. ;
Shafat, Manar S. ;
Mehta, Tarang K. ;
Di Palma, Federica ;
Lawes, Matthew J. ;
Rushworth, Stuart A. ;
Bowles, Kristian M. .
CANCER RESEARCH, 2017, 77 (02) :303-311
[3]   Molecular Mechanisms Underlying IL-33-Mediated Inflammation in Inflammatory Bowel Disease [J].
Aggeletopoulou, Ioanna ;
Tsounis, Efthymios P. P. ;
Triantos, Christos .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)
[4]   Interleukin-27 and interleukin-35 in de novo acute myeloid leukemia: expression and significance as biological markers [J].
Ahmed, Heba A. ;
Maklad, Ahmed M. ;
Khaled, Safaa A. A. ;
Elyamany, Ashraf .
JOURNAL OF BLOOD MEDICINE, 2019, 10 :341-349
[5]   IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes [J].
Apert, Cecile ;
Romagnoli, Paola ;
van Meerwijk, Joost P. M. .
PROTEIN & CELL, 2018, 9 (04) :322-332
[6]   Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein [J].
Bachanova, Veronika ;
Cooley, Sarah ;
Defor, Todd E. ;
Verneris, Michael R. ;
Zhang, Bin ;
McKenna, David H. ;
Curtsinger, Julie ;
Panoskaltsis-Mortari, Angela ;
Lewis, Dixie ;
Hippen, Keli ;
McGlave, Philip ;
Weisdorf, Daniel J. ;
Blazar, Bruce R. ;
Miller, Jeffrey S. .
BLOOD, 2014, 123 (25) :3855-3863
[7]   Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor-κB in acute myeloid leukemia-derived predendritic KG-1 cells [J].
Bachmann, Malte ;
Dragoi, Cristina ;
Poleganov, Marco A. ;
Pfeilschifter, Josef ;
Muehl, Heiko .
MOLECULAR CANCER THERAPEUTICS, 2007, 6 (02) :723-731
[8]   IL-10-producing T cells and their dual functions [J].
Bedke, Tanja ;
Muscate, Franziska ;
Soukou, Shiwa ;
Gagliani, Nicola ;
Huber, Samuel .
SEMINARS IN IMMUNOLOGY, 2019, 44
[9]   Bone and the hematopoietic niche: a tale of two stem cells [J].
Bianco, Paolo .
BLOOD, 2011, 117 (20) :5281-5288
[10]   Expand to shield: IL-15 and in situ lymphocytic proliferation [J].
Bindea, Gabriela ;
Mlecnik, Bernhard ;
Galon, Jerome .
ONCOIMMUNOLOGY, 2021, 10 (01)
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