Down-regulation of human long non-coding RNA LINC01187 is associated with nephropathies

被引：2

作者：

Manolakou, Theodora ^{[1
,2
,3
]}

Kaltezioti, Valeria ^{[2
]}

Prakoura, Niki ^{[4
]}

Kavvadas, Panagiotis ^{[4
]}

Reichelt-Wurm, Simone ^{[5
]}

Gakiopoulou, Harikleia ^{[6
]}

Banas, Miriam ^{[5
]}

Banas, Bernhard ^{[5
]}

Lindenmeyer, Maja T. ^{[7
]}

Cohen, Clemens D. ^{[8
]}

Boor, Peter ^{[9
,10
]}

Djudjaj, Sonja ^{[9
]}

Boumpas, Dimitrios T. ^{[2
,11
]}

Chatziantoniou, Christos ^{[4
,12
,13
]}

Charonis, Aristidis ^{[2
,14
,15
]}

Politis, Panagiotis K. ^{[1
,16
]}

机构：

[1] Biomed Res Fdn Acad Athens, Ctr Basic Res, Athens, Greece

[2] Biomed Res Fdn Acad Athens, Ctr Clin Expt Surg & Translat Res, Athens, Greece

[3] Natl & Kapodistrian Univ Athens, Sch Med, Athens, Greece

[4] Tenon Hosp, Batiment Rech, Paris, France

[5] Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany

[6] Natl & Kapodistrian Univ Athens, Sch Med, Dept Pathol 1, Athens, Greece

[7] Univ Med Ctr Hamburg Eppendorf, Dept Med 3, Hamburg, Germany

[8] Univ Hosp Munich, Nephrol Ctr, Med Clin & Policlin 4, Munich, Germany

[9] RWTH Aachen Univ Hosp, Inst Pathol, Aachen, Germany

[10] RWTH Aachen Univ Hosp, Dept Nephrol & Immunol, Aachen, Germany

[11] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Rheumatol & Clin Immunol Unit,Dept Internal Med 4, Athens, Greece

[12] Sorbonne Univ, Fac Med, Paris, France

[13] Tenon Hosp, Inst Natl Sante & Rech Med INSERM, Unite Mixte Rech Sci 1155, Paris, France

[14] Univ Res Inst Maternal & Child Hlth & Precis Med, Athens, Greece

[15] Biomed Res Fdn Acad Athens, Ctr Clin Expt Surg & Translat Res, 4 Soranou Efesiou Str, Athens 11527, Greece

[16] Biomed Res Fdn Acad Athens, Ctr Basic Res, 4 Soranou Efesiou Str, Athens 11527, Greece

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2023年 / 27卷 / 09期

基金：

欧洲研究理事会;

关键词：

apoptosis; Gm12121; in situ hybridization; LINC01187; long non-coding RNAs; renal diseases; EXPRESSION; IDENTIFICATION; PATHOPHYSIOLOGY; ACIDOSIS; DISEASE;

D O I：

10.1111/jcmm.17014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chronic kidney diseases affect a substantial percentage of the adult population worldwide. This observation emphasizes the need for novel insights into the molecular mechanisms that control the onset and progression of renal diseases. Recent advances in genomics have uncovered a previously unanticipated link between the non-coding genome and human kidney diseases. Here we screened and analysed long non-coding RNAs (lncRNAs) previously identified in mouse kidneys by genome-wide transcriptomic analysis, for conservation in humans and differential expression in renal tissue from healthy and diseased individuals. Our data suggest that LINC01187 is strongly down-regulated in human kidney tissues of patients with diabetic nephropathy and rapidly progressive glomerulonephritis, as well as in murine models of kidney diseases, including unilateral ureteral obstruction, nephrotoxic serum-induced glomerulonephritis and ischemia/reperfusion. Interestingly, LINC01187 overexpression in human kidney cells in vitro inhibits cell death indicating an anti-apoptotic function. Collectively, these data suggest a negative association of LINC01187 expression with renal diseases implying a potential protective role.

引用

页码：1192 / 1205

页数：14

共 45 条

[1] Update on Lupus Nephritis [J].

Almaani, Salem ;

Meara, Alexa ;

Rovin, Brad H. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 12 (05) :825-835

[2]

[Anonymous], 2013, Kidney International Supplements, V3, P19, DOI [10.1038/kisup.2012.64.2011, DOI 10.1038/KISUP.2012.64.2011, DOI 10.1038/KISUP.2012.64]

[3] Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases [J].

Arvaniti, Eleni ;

Moulos, Panagiotis ;

Vakrakou, Athina ;

Chatziantoniou, Christos ;

Chadjichristos, Christos ;

Kavvadas, Panagiotis ;

Charonis, Aristidis ;

Politis, Panagiotis K. .

SCIENTIFIC REPORTS, 2016, 6

[4] Long Noncoding RNAs: Cellular Address Codes in Development and Disease [J].

Batista, Pedro J. ;

Chang, Howard Y. .

CELL, 2013, 152 (06) :1298-1307

[5] Effective CKD Care in European Countries: Challenges and Opportunities for Health Policy [J].

Bello, Aminu K. ;

Levin, Adeera ;

Manns, Braden J. ;

Feehally, John ;

Drueke, Tilman ;

Faruque, Labib ;

Hemmelgarn, Brenda R. ;

Kernahan, Charles ;

Mann, Johannes ;

Klarenbach, Scott ;

Remuzzi, Giuseppe ;

Tonelli, Marcello .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2015, 65 (01) :15-25

[6] Pathophysiology of hypertensive renal damage - Implications for therapy [J].

Bidani, AK ;

Griffin, KA .

HYPERTENSION, 2004, 44 (05) :595-601

[7] Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1 [J].

Blomqvist, SR ;

Vidarsson, H ;

Fitzgerald, S ;

Johansson, BR ;

Ollerstam, A ;

Brown, R ;

Persson, AEG ;

Bergström, G ;

Enerbäck, S .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (11) :1560-1570

[8] Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins [J].

Cohen, CD ;

Klingenhoff, A ;

Boucherot, A ;

Nitsche, A ;

Henger, A ;

Brunner, B ;

Schmid, H ;

Merkle, M ;

Saleem, MA ;

Koller, KP ;

Werner, T ;

Gröne, HJ ;

Nelson, PJ ;

Kretzler, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (15) :5682-5687

[9] Quantitative gene expression analysis in renal biopsies:: A novel protocol for a high-throughput multicenter application [J].

Cohen, CD ;

Frach, K ;

Schlöndorff, D ;

Kretzler, M .

KIDNEY INTERNATIONAL, 2002, 61 (01) :133-140

[10] The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression [J].

Derrien, Thomas ;

Johnson, Rory ;

Bussotti, Giovanni ;

Tanzer, Andrea ;

Djebali, Sarah ;

Tilgner, Hagen ;

Guernec, Gregory ;

Martin, David ;

Merkel, Angelika ;

Knowles, David G. ;

Lagarde, Julien ;

Veeravalli, Lavanya ;

Ruan, Xiaoan ;

Ruan, Yijun ;

Lassmann, Timo ;

Carninci, Piero ;

Brown, James B. ;

Lipovich, Leonard ;

Gonzalez, Jose M. ;

Thomas, Mark ;

Davis, Carrie A. ;

Shiekhattar, Ramin ;

Gingeras, Thomas R. ;

Hubbard, Tim J. ;

Notredame, Cedric ;

Harrow, Jennifer ;

Guigo, Roderic .

GENOME RESEARCH, 2012, 22 (09) :1775-1789

← 1 2 3 4 5 →