Emerging therapies in dyslipidaemias

被引：3

作者：

Catapano, Alberico L. ^{[1
,2
]}

机构：

[1] IRCCS MultiMed, Milan, Italy

[2] Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy

来源：

VASCULAR PHARMACOLOGY | 2023年 / 153卷

关键词：

Low-density lipoprotein cholesterol; Lipid-lowering therapies; Triglycerides; Lipoprotein(a);

D O I：

10.1016/j.vph.2023.107229

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several observations have shown that elevated levels of low-density lipoprotein cholesterol (LDL-C) are a cause of cardiovascular disease. Lowering LDL-C is a key strategy for reducing cardiovascular risk, with a continuous linear correlation between LDL-C reduction and cardiovascular benefit. Based on these observations, current guidelines have further lowered LDL-C goals and call for the use of more effective therapeutic interventions. In addition to statins, ezetimibe and the monoclonal antibodies targeting PCSK9, several new lipid-lowering agents are currently in phase 3 clinical trials to evaluate their clinical effects, and more are in development. The use of combination therapies targeting different pathways can increase the effectiveness of treatment.

引用

页数：3

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