Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice

被引:55
作者
Chen, Guangquan [1 ,2 ]
Xiong, Shiyi [1 ,2 ]
Jing, Qiao [3 ]
van Gestel, Cornelis A. M. [4 ]
van Straalen, Nico M. [4 ]
Roelofs, Dick [5 ]
Sun, Luming [1 ,2 ,6 ]
Qiu, Hao [6 ]
机构
[1] Tongji Univ, Shanghai Matern & Infant Hosp 1, Sch Med, Shanghai Key Lab Maternal Fetal Med,Dept Fetal Med, Shanghai 201204, Peoples R China
[2] Tongji Univ, Shanghai Matern & Infant Hosp 1, Prenatal Diag Ctr, Sch Med, Shanghai 201204, Peoples R China
[3] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Pediat, Shanghai 200120, Peoples R China
[4] Vrije Univ Amsterdam, Amsterdam Inst Life & Environm A LIFE, Fac Sci, Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands
[5] KeyGene, Agro Business Pk 90, NL-6708 PW Wageningen, Netherlands
[6] Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China
基金
中国国家自然科学基金;
关键词
Nanoplastics; Fetal growth restriction; Placenta; Toxicogenomics; Toxicometabolomics; APOLIPOPROTEIN A-IV; GENE-EXPRESSION; MICROPLASTICS; PHYSIOLOGY;
D O I
10.1016/j.scitotenv.2022.158666
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Microplastics can enter the human body via direct body contact or the food chain, increasing the likelihood of adverse impacts on pregnancy and fetal development. We investigated the potential effects and modes of action of polystyrene nanoplastics (PS-NPs) in placenta and fetus using mice as a model species. Maternal PS-NP exposure (100 nm; 1 and 10 mg/L) via drinking water induced a significant decline in fetal weights at the higher exposure concentration. Ab-normal morphologies of cells in the placenta and fetus were observed after exposure. For the placenta, transcriptomic analyses indicated that PS-NPs significantly disturbed cholesterol metabolism and complement and coagulation cas-cades pathways. Metabolomics showed appreciable metabolic disorders, particularly affecting sucrose and daidzein concentrations. For the fetal skeletal muscle, transcriptomics identified many significantly regulated genes, involving muscle tissue development, lipid metabolism, and skin formation. Transcriptomic analysis of the placenta and fetal skeletal muscle at the high PS-NP concentration showed that APOA4 and its transcriptional factors, facilitating cholesterol transportation, were significantly regulated in both tissues. Our study revealed that PS-NPs caused fetal growth restriction and significantly disturbed cholesterol metabolism in both placenta and fetus, offering new insights into the mechanisms underlying the placental and fetal effects in mice exposed to PS-NPs.
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页数:13
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