A pH-Responsive Nanoplatform Based on Magnetic Mesoporous Silica Nanoparticles for Enhanced Treatment of Pancreatic Cancer

被引：10
作者：
Qi, Guiqiang [1 ]
Wang, Shengchao [1 ]
Yin, Qiangqiang [1 ]
Zhang, Zhichen [1 ]
Wen, Xianchun [2 ]
Hao, Liguo [1 ]
机构：
[1] Qiqihar Med Univ, Sch Med Technol, Dept Mol Imaging, Qiqihar 161006, Peoples R China
[2] Qiqihar Med Univ, Sch Med Technol, Qiqihar 161006, Peoples R China
来源：
ACS APPLIED NANO MATERIALS | 2023年 / 6卷 / 24期
关键词：
Nanoplatform; pH-responsive; Pancreatic cancer; Targeted therapy; Multimodal imaging; DRUG-DELIVERY; RELEASE;
D O I：
10.1021/acsanm.3c04596
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
This study presents the pH-responsive nanoplatform DOX@M-MSN-5-FAM@PDA (DM-F@P) to improve the treatment of pancreatic cancer. DM-F@P is a combination of magnetic mesoporous silica nanoparticles (M-MSN) and a pH-responsive polydopamine (PDA) outer layer to ensure the controlled delivery of loaded drugs. The combination of doxorubicin (DOX) and 5-carboxyfluorescein (5-FAM) fluorescent dyes in DM-F@P imparts chemotherapy and fluorescence imaging capabilities. The pH-responsive PDA shell permits the controlled release of DOX, specifically in the tumor microenvironment, thereby enabling accurate treatment. Moreover, PDA is highly biocompatible. In vitro and in vivo research has confirmed the powerful effectiveness of DM-F@P against pancreatic cancer and its minimal toxicity toward normal cells. Additionally, the magnetic Fe3O4 component of DM-F@P enabled magnetic resonance imaging (MRI). This innovative nanomaterial provides an integrated diagnostic platform that combines therapeutic and imaging capabilities; therefore, it is considered a modality that facilitates pancreatic cancer diagnosis and treatment.
引用
收藏
页码：23184 / 23195
页数：12
相关论文
共 41 条
[1]   Optimized Doxorubicin Chemotherapy for Diffuse Large B-cell Lymphoma Exploits Nanocarrier Delivery to Transferrin Receptors [J].
Arumov, Artavazd ;
Liyanage, Piumi Y. ;
Trabolsi, Asaad ;
Roberts, Evan R. ;
Li, Lingxiao ;
Ferreira, Braulio C. L. B. ;
Gao, Zhen ;
Ban, Yuguang ;
Newsam, Austin D. ;
Taggart, Melissa W. ;
Vega, Francisco ;
Bilbao, Daniel ;
Leblanc, Roger M. ;
Schatz, Jonathan H. .
CANCER RESEARCH, 2021, 81 (03) :763-775
[2]   Defining Value for Pancreatic Surgery in Early-Stage Pancreatic Cancer [J].
Bateni, Sarah B. ;
Gingrich, Alicia A. ;
Hoch, Jeffrey S. ;
Canter, Robert J. ;
Bold, Richard J. .
JAMA SURGERY, 2019, 154 (10)
[3]   Construction of a ratiometric fluorescent probe for visual detection of urea in human urine based on carbon dots prepared from Toona sinensis leaves and 5-carboxyfluorescein [J].
Bei, Yuyang ;
Arkin, Kamile ;
Zheng, Yuxin ;
Ma, Xuesong ;
Zhao, Jie ;
Jin, Huimin ;
Shang, Qingkun .
ANALYTICA CHIMICA ACTA, 2023, 1240
[4]   Aptamer-Dendrimer Functionalized Magnetic Nano-Octahedrons: Theranostic Drug/Gene Delivery Platform for Near-Infrared/Magnetic Resonance Imaging-Guided Magnetochemotherapy [J].
Chen, Zhongyuan ;
Peng, Yueting ;
Li, Yichao ;
Xie, Xiaoxue ;
Wei, Xiaodan ;
Yang, Geng ;
Zhang, Hanxi ;
Li, Ningxi ;
Li, Tingting ;
Qin, Xiang ;
Li, Shun ;
Wu, Chunhui ;
You, Fengming ;
Yang, Hong ;
Liu, Yiyao .
ACS NANO, 2021, 15 (10) :16683-16696
[5]   pH-Sensitive Delivery Vehicle Based on Folic Acid-Conjugated Polydopamine-Modified Mesoporous Silica Nanoparticles for Targeted Cancer Therapy [J].
Cheng, Wei ;
Nie, Junpeng ;
Xu, Lv ;
Liang, Chaoyu ;
Peng, Yunmei ;
Liu, Gan ;
Wang, Teng ;
Mei, Lin ;
Huang, Laiqiang ;
Zeng, Xiaowei .
ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (22) :18462-18473
[6]   Five-Year Outcomes of FOLFIRINOX vs Gemcitabine as Adjuvant Therapy for Pancreatic Cancer A Randomized Clinical Trial [J].
Conroy, Thierry ;
Castan, Florence ;
Lopez, Anthony ;
Turpin, Anthony ;
Ben Abdelghani, Meher ;
Wei, Alice C. ;
Mitry, Emmanuel ;
Biagi, James J. ;
Evesque, Ludovic ;
Artru, Pascal ;
Lecomte, Thierry ;
Assenat, Eric ;
Bauguion, Lucile ;
Ychou, Marc ;
Bouche, Olivier ;
Monard, Laure ;
Lambert, Aurelien ;
Hammel, Pascal .
JAMA ONCOLOGY, 2022, 8 (11) :1571-1578
[7]   mRNA Delivery by a pH-Responsive DNA Nano-Hydrogel [J].
Fu, Xin ;
Chen, Tianshu ;
Song, Yuchen ;
Feng, Chang ;
Chen, Huinan ;
Zhang, Qianqian ;
Chen, Guifang ;
Zhu, Xiaoli .
SMALL, 2021, 17 (29)
[8]   Acetal containing polymers as pH-responsive nano-drug delivery systems [J].
Gannimani, Ramesh ;
Walvekar, Pavan ;
Naidu, Veluru Ramesh ;
Aminabhavi, Tejraj M. ;
Govender, Thirumala .
JOURNAL OF CONTROLLED RELEASE, 2020, 328 :736-761
[9]   Enzyme-responsive nano-drug delivery system for combined antitumor therapy [J].
Guo, Fangyuan ;
Jiao, Yunlong ;
Du, Yinzhou ;
Luo, Shuai ;
Hong, Weiyong ;
Fu, Qiafan ;
Li, Aiqin ;
Wang, Guoping ;
Yang, Gensheng .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 220 :1133-1145
[10]   Pancreatic cancer: Advances and challenges [J].
Halbrook, Christopher J. ;
Lyssiotis, Costas A. ;
di Magliano, Marina Pasca ;
Maitra, Anirban .
CELL, 2023, 186 (08) :1729-1754
12345