Methylenetetrahydrofolate Reductase Gene Polymorphism as a Risk Factor for Coronary Artery Disease

被引：0
作者：
Sowndarya, K. [1 ]
Manjrekar, Poornima A. [1 ]
Shenoy, Ramya [2 ]
Hegde, Anupama [1 ]
机构：
[1] Manipal Acad Higher Educ, Kasturba Med Coll Mangalore, Dept Biochem, Manipal 575004, Karnataka, India
[2] Manipal Acad Higher Educ, Manipal Coll Dent Sci Mangalore, Dept Publ Hlth Dent, Manipal, Karnataka, India
来源：
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY | 2025年 / 40卷 / 01期
关键词：
Coronary artery disease; Homocysteine; MTHFR; SNP; HOMOCYSTEINE LEVELS; C677T POLYMORPHISM; MTHFR; HEALTHY; IMPACT; POPULATION; CAD;
D O I：
10.1007/s12291-023-01162-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hyperhomocysteinemia (HHcy) is one of the factors contributing to the pathogenesis of coronary artery disease (CAD). Besides nutritional deficiency disorders, genetic polymorphism predominantly related to point mutation in the gene coding for Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the metabolism methionine-homocysteine (Hcy) has been implicated in HHcy. PubMed survey related to MTHFR gene polymorphism in CAD retrieved 143 articles from which 20 were selected in which MTHFR gene polymorphism and Hcy were estimated. The selected studies had estimated either MTHFRC677T or A1298C or both. All the studies detected presence of MTHFRC677T in CAD. Hcy levels were found to range from normal to HHcy with debatable association to CAD.
引用
收藏
页码：25 / 31
页数：7
相关论文
共 50 条
  • [21] Methylenetetrahydrofolate Reductase C667T Polymorphism is Associated with Increased Risk of Coronary Artery Disease in a Chinese Population
    Chen, W.
    Hua, K.
    Gu, H.
    Zhang, J.
    Wang, L.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2014, 80 (05) : 346 - 353
  • [22] Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis
    Elias Zintzaras
    Katrin Uhlig
    George N. Koukoulis
    Afroditi A. Papathanasiou
    Ioannis Stefanidis
    Journal of Human Genetics, 2007, 52 : 881 - 890
  • [23] Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis
    Zintzaras, Elias
    Uhlig, Katrin
    Koukoulis, George N.
    JOURNAL OF HUMAN GENETICS, 2007, 52 (11) : 881 - 890
  • [24] The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease
    Gardemann, A
    Weidemann, H
    Philipp, M
    Katz, N
    Tillmanns, H
    Hehrlein, FW
    Haberbosch, W
    EUROPEAN HEART JOURNAL, 1999, 20 (08) : 584 - 592
  • [25] Methylenetetrahydrofolate reductase gene polymorphism in diabetes and obesity
    Javad Tavakkoly Bazzaz
    Mahnaz Shojapoor
    Habibollah Nazem
    Parvin Amiri
    Hossein Fakhrzadeh
    Ramin Heshmat
    Maryam Parvizi
    Shirin Hasani Ranjbar
    Mahsa M. Amoli
    Molecular Biology Reports, 2010, 37 : 105 - 109
  • [26] Gene Polymorphisms of Methylenetetrahydrofolate Reductase and Apolipoprotein E: Causes or Markers for Coronary Artery Disease?
    Chen, Jan-Yow
    Liou, Ying-Ming
    Chang, Kuan-Cheng
    CARDIOLOGY, 2019, 142 (04) : 208 - 210
  • [27] Methylenetetrahydrofolate reductase gene polymorphism is not related to the risk of ischemic cerebrovascular disease in a Brazilian population
    Nagahashi Marie, Suely Kazue
    Shinjo, Samuel Katsuyuki
    Oba-Shinjo, Sueli Mieko
    da Silva, Roseli
    Barbosa, Keila Cardoso
    Yamamoto, Fabio
    Scaff, Milberto
    CLINICS, 2007, 62 (03) : 295 - 300
  • [28] A methylenetetrahydrofolate reductase gene polymorphism in ischaemic stroke and in carotid artery stenosis
    Kostulas, K
    Crisby, M
    Huang, WX
    Lannfelt, L
    Hagenfeldt, L
    Eggertsen, G
    Kostulas, V
    Hillert, J
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1998, 28 (04) : 285 - 289
  • [29] THERMOLABILE DEFECT OF METHYLENETETRAHYDROFOLATE REDUCTASE IN CORONARY-ARTERY DISEASE
    KANG, SS
    PASSEN, EL
    RUGGIE, N
    WONG, PWK
    SORA, H
    CIRCULATION, 1993, 88 (04) : 1463 - 1469
  • [30] A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease
    Brown, CA
    McKinney, KQ
    Kaufman, JS
    Gravel, RA
    Rozen, R
    JOURNAL OF CARDIOVASCULAR RISK, 2000, 7 (03): : 197 - 200
12345