N6-methyladenosine (m6A) modification in Natural immune cell-mediated inflammatory diseases

被引：5
作者：
Teng, Yan [1 ,2 ]
Yi, Jin [3 ]
Chen, Junnian [2 ]
Yang, Lu [1 ,2 ]
机构：
[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Inst Neurol, Chengdu 610072, Sichuan, Peoples R China
[2] Univ Elect Sci & Technol China, Sch Med, 4,Sect 2,North Jianshe Rd, Chengdu 610054, Sichuan, Peoples R China
[3] Univ Elect Sci & Technol China, Ctr Informat Biol, Sch Life Sci & Technol, Chengdu 640054, Sichuan, Peoples R China
来源：
JOURNAL OF INNATE IMMUNITY | 2023年 / 15卷 / 01期
基金：
中国国家自然科学基金;
关键词：
m6A; Innate immune cell; Inflammatory disease; HEPATITIS-B; MACROPHAGES; METHYLATION; RNAS;
D O I：
10.1159/000534162
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability, transport and translation with implications for various physiological and pathological processes. Immune cell development, differentiation and activation are also thought to be regulated by m6A and affect host defense against pathogens and inflammatory response with impacts on infectious, neoplastic, autoimmune, cardiovascular, hepatic and osteal diseases. The current review summarizes recent research on m6A in monocyte/macrophages, neutrophils, dendritic cells, natural killer cells and microglia and gives insights into epigenetic modifications of the immune system and novel therapeutic strategies for immune-related diseases.
引用
收藏
页码：804 / 821
页数：18
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