1,2,3-Triazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones and 6,7-Dihydrobenzo[d]isoxazol-4(5H)-ones: Synthesis and Biological Activity

被引：0

作者：

Khlebnicova, T. S. ^{[1
]}

Zinovich, V. G. ^{[1
]}

Piven, Yu. A. ^{[1
]}

Baranovsky, A. V. ^{[1
]}

Lakhvich, F. A. ^{[1
]}

Trifonov, R. E. ^{[2
]}

Golubeva, Yu. A. ^{[3
,4
]}

Klyushova, L. S. ^{[4
]}

Lider, E. V. ^{[3
]}

机构：

[1] Natl Acad Sci Belarus, Inst Bioorgan Chem, Minsk 220084, BELARUS

[2] Tech Univ, St Petersburg State Inst Technol, St Petersburg 190013, Russia

[3] Russian Acad Sci, AV Nikolaev Inst Inorgan Chem, Siberian Branch, Novosibirsk 630090, Russia

[4] Fed Res Ctr Fundamental & Translat Med, Inst Mol Biol & Biophys, Novosibirsk 630060, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

1; 5; 6; 7-tetrahydro-4H-indazol-4-ones; 7-dihydrobenzo[d]isoxazol-4(5H)-ones; 2; 3-triazoles; 2-[(1H-1; 3-triazol-1-yl)acetyl]cyclohexane-1; 3-diones; cytotoxic activity; cytostatic activity; DERIVATIVES; INDAZOLE; TRIAZOLE;

D O I：

10.1134/S1070363223020068

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triazole-containing 1,5,6,7-tetrahydro-4H-indazol-4-ones and 6,7-dihydrobenzo[d]isoxazol-4(5H)-ones were synthesized by cyclocondensation of 2-[(1H-1,2,3-triazol-1-yl)acetyl]cyclohexane-1,3-diones with phenylhydrazine (4-fluorophenylhydrazine) or hydroxylamine, respectively. Structure and composition of the obtained compounds were confirmed by H-1, C-13, F-19 NMR spectroscopy methods and by data of elemental analysis. Cytotoxic and cytostatic activities of the series of obtained compounds were investigated in vitro against human hepatocellular carcinoma cells HepG2, mammary adenocarcinoma cells MCF-7, and laryngeal cancer cells Hep2.

引用

页码：268 / 277

页数：10

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