The effect of tacrolimus conversion from immediate- to extended-release formulation on renal function in renal transplant patients: a meta-analysis

被引:2
作者
Chao, Sheng [1 ]
Jia, Lei [1 ]
Zhu, Kejing [1 ]
Chen, Luobei [1 ]
Niu, Yulin [1 ]
机构
[1] Guizhou Med Univ, Affiliated Hosp, Dept Organ Transplantat, Guiyang, Peoples R China
关键词
renal transplant; extended-release tacrolimus; immediate-release tacrolimus; serum creatinine; estimated glomerular filtration rate; TWICE-DAILY TACROLIMUS; KIDNEY;
D O I
10.3389/fphar.2023.1226647
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objective: Tacrolimus formulation affects the outcomes of a renal transplant, while the effect of its immediate- to extended-release conversion remains controversial. This meta-analysis aimed to compare the renal function before and after tacrolimus immediate- to extended-release conversion in renal transplant patients.Methods: PubMed, Cochrane, Embase, CNKI, CQVIP, and Wanfang databases were searched for articles regarding the effect of tacrolimus conversion from immediate- to extended-release formulation on renal function in renal transplant patients. The data on serum creatinine (Scr) or the estimated glomerular filtration rate (eGFR) before and after conversion were extracted and analyzed.Results: Ten studies with 743 renal transplant patients were included. Scr was reduced after conversion versus before conversion [mean difference (MD) (95% confidence interval (CI)): -8.00 (-14.33; -1.66) mu mol/L, p = 0.01]. However, eGFR only showed an increased trend after conversion versus before conversion (MD (95% CI): 2.21 (-1.62, 6.03) mL/min/1.73 m(2), p = 0.26) but without statistical significance. Furthermore, in patients with a follow-up duration >= 48 weeks, Scr was decreased after conversion versus before conversion (p = 0.005), but eGFR remained unchanged (p = 0.68). However, in patients with a follow-up duration <48 weeks, both Scr (p = 0.36) and eGFR (p = 0.24) were not different before conversion versus after conversion. Moreover, publication bias risk was low, and robustness assessed by sensitivity analysis was generally good.Conclusion: This meta-analysis favors studies indicating that the conversion of tacrolimus from an immediate-release to an extended-release formulation could improve the kidney function to some extent in renal transplant patients, and this advancement may be related to the administration period.
引用
收藏
页数:10
相关论文
共 37 条
  • [1] Immunosuppression Adherence in Stable Kidney Transplant Patients Converted From Immediate- to Prolonged-Release Tacrolimus in Clinical Practice: A Norwegian Study
    Abedini, Sadollah
    Goransson, Lasse
    Cockburn, Elinor
    Kilany, Suzanne
    Holdaas, Hallvard
    [J]. TRANSPLANTATION DIRECT, 2018, 4 (02):
  • [2] Long-Term Kidney Transplant Outcomes: Role of Prolonged-Release Tacrolimus
    Banas, Bernhard
    Kraemer, Bernhard K.
    Krueger, Bernd
    Kamar, Nassim
    Undre, Nasrullah
    [J]. TRANSPLANTATION PROCEEDINGS, 2020, 52 (01) : 102 - 110
  • [3] Prolonged-Release Once-Daily Formulation of Tacrolimus Versus Standard-of-Care Tacrolimus in de novo Kidney Transplant Patients Across Europe
    Budde, Klemens
    Rostaing, Lionel
    Maggiore, Umberto
    Piotti, Giovanni
    Surace, Daniela
    Geraci, Silvia
    Procaccianti, Claudio
    Nicolini, Gabriele
    Witzke, Oliver
    Kamar, Nassim
    Albano, Laetitia
    Buchler, Matthias
    Pascual, Julio
    Gutierrez-Dalmau, Alex
    Kuypers, Dirk
    Wekerle, Thomas
    Glyda, Maciej
    Carmellini, Mario
    Tisone, Giuseppe
    Midtvedt, Karsten
    Wennberg, Lars
    Grinyo, Josep M.
    [J]. TRANSPLANT INTERNATIONAL, 2022, 35 (01)
  • [4] Chenguang D., 2021, Prac. J. Organ Transpl. Electron. Version), V9, P281, DOI [10.3969/j.issn.2095-5332.2021.04.006, DOI 10.3969/J.ISSN.2095-5332.2021.04.006]
  • [5] Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients:: a literature review
    Denhaerynck, K
    Dobbels, F
    Cleemput, I
    Desmyttere, A
    Schäfer-Keller, P
    Schaub, S
    De Geest, S
    [J]. TRANSPLANT INTERNATIONAL, 2005, 18 (10) : 1121 - 1133
  • [6] Efficacy and Safety of Once-Daily LCP-Tacrolimus Versus Twice-Daily Immediate-Release Tacrolimus in Adult Hispanic Stable Kidney Transplant Recipients: Sub-Group Analysis from a Phase 3 Trial
    Faravardeh, Arman
    Akkina, Sanjeev
    Villicana, Rafael
    Guerra, Giselle
    Moten, Misbah A.
    Meier-Kriesche, Ulf
    Stevens, Daniel R.
    Patel, Samir J.
    Bunnapradist, Suphamai
    [J]. ANNALS OF TRANSPLANTATION, 2021, 26
  • [7] Conversion From Twice-Daily Tacrolimus Capsules to Once-Daily Extended-Release Tacrolimus (LCPT): A Phase 2 Trial of Stable Renal Transplant Recipients
    Gaber, A. Osama
    Alloway, Rita R.
    Bodziak, Kenneth
    Kaplan, Bruce
    Bunnapradist, Suphamai
    [J]. TRANSPLANTATION, 2013, 96 (02) : 191 - 197
  • [8] Tacrolimus Prolonged Release (Envarsus®): A Review of Its Use in Kidney and Liver Transplant Recipients
    Garnock-Jones, Karly P.
    [J]. DRUGS, 2015, 75 (03) : 309 - 320
  • [9] Goldfarb DA, 2021, J UROLOGY, V206, P760, DOI 10.1097/JU.0000000000001917
  • [10] Guo X., 2021, CHIN J ORGAN TRANSPL, V42, P104, DOI [DOI 10.3760/CMA.J.CN421203-20201103-00377, 10.3760/cma.j.cn421203-20201103-00377]