Brodalumab for the Treatment of Moderate-to-Severe Psoriasis: An Expert Delphi Consensus Statement

被引：11

作者：

Fargnoli, Maria Concetta ^{[1
,2
]}

Bardazzi, Federico ^{[3
]}

Bianchi, Luca ^{[4
,5
]}

Dapavo, Paolo ^{[6
]}

Fabbrocini, Gabriella ^{[7
]}

Gisondi, Paolo ^{[8
]}

Micali, Giuseppe ^{[9
]}

Offidani, Anna Maria ^{[10
]}

Pellacani, Giovanni ^{[11
]}

Skroza, Nevena ^{[12
]}

Angileri, Rosa Giuseppa ^{[13
]}

Burlando, Martina ^{[14
]}

Campanati, Anna ^{[15
]}

Carrera, Carlo Giovanni ^{[16
]}

Chiricozzi, Andrea ^{[17
,18
]}

Conti, Andrea ^{[19
]}

Simone, Clara De ^{[17
,18
]}

Di Lernia, Vito ^{[20
]}

Errichetti, Enzo ^{[21
]}

Galluzzo, Marco ^{[4
,5
]}

Guarneri, Claudio ^{[22
]}

Lasagni, Claudia ^{[23
]}

Lembo, Serena ^{[24
]}

Loconsole, Francesco ^{[25
,26
]}

Megna, Matteo ^{[7
]}

Musumeci, Maria Letizia ^{[9
]}

Prignano, Francesca ^{[27
]}

Richetta, Antonio Giovanni ^{[28
]}

Trovato, Emanuele ^{[29
]}

Venturini, Marina ^{[30
]}

Peris, Ketty ^{[17
,18
]}

Pinton, Piergiacomo Calzavara ^{[30
]}

机构：

[1] Univ Laquila, Dept Biotechnol & Appl Clin Sci, I-67100 Laquila, Italy

[2] Osped San Salvatore, Dermatol Unit, I-67100 Laquila, Italy

[3] IRCCS Azienda Osped Univ Bologna, Dermatol Unit, Policlin S Orsola Malpighi, I-40126 Bologna, Italy

[4] Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy

[5] Azienda Osped Univ Policlin Tor Vergata, Dermatol Unit, I-00133 Rome, Italy

[6] Univ Turin, Dept Med Sci, Dermatol Clin, I-10124 Turin, Italy

[7] Univ Naples Federico II, Dept Clin Med & Surg, Sect Dermatol, I-80138 Naples, Italy

[8] Univ Verona, Dept Med, Sect Dermatol & Venereol, I-37129 Verona, Italy

[9] Univ Catania, Dept Dermatol, I-95123 Catania, Italy

[10] Polytech Marche Univ, Dept Clin & Mol Sci, Dermatol Unit, I-60121 Ancona, Italy

[11] Sapienza Univ Rome, Sapienza Med Sch, Dept Clin Internal Anesthesiol & Cardiovasc Sci, Dermatol Clin, I-00185 Rome, Italy

[12] Sapienza Univ Rome Polo Pontino, Dept Med & Surg Sci & Biotechnol, Dermatol Unit D Innocenzi, I-04100 Latina, Italy

[13] ARNAS Civ Palermo, UOC Dermatol, I-90127 Palermo, Italy

[14] Osped Policlin San Martino IRCCS, Clin Dermatolog, DissaL, I-16132 Genoa, Italy

[15] Polytech Marche Univ, Dept Clin & Mol Sci, Dermatol Clin, I-60121 Ancona, Italy

[16] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Internal Med, Dermatol Unit, I-20122 Milan, Italy

[17] Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslazionale, Dermatol, I-00168 Rome, Italy

[18] Fdn Policlin Univ A Gemelli, Dipartimento Sci Med & Chirurg, UOC Dermatol, IRCCS, I-00168 Rome, Italy

[19] Infermi Hosp, Dept Surg, Dermatol Unit, AUSL Romagna, I-47923 Rimini, Italy

[20] Arcispedale S Maria Nuova Azienda USL IRCCS Reggio, Dermatol Unit, I-42122 Reggio Emilia, Italy

[21] Univ Udine, Inst Dermatol, Azienda Sanit Univ Friuli Cent ASU FC, I-33100 Udine, Italy

[22] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, I-98122 Messina, Italy

[23] AOU Policlin Modena, Clin Dermatolog, Dipartimento Med Specialist, I-41121 Modena, Italy

[24] Univ Salerno, Scuola Med Salernitana, Dept Med Surg & Dent, I-84084 Fisciano, Italy

[25] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, I-70121 Bari, Italy

[26] Azienda Osped Univ Consorziale Policlin Bari, I-70124 Bari, Italy

[27] Univ Florence, Dept Hlth Sci, Sect Dermatol, I-50125 Florence, Italy

[28] Sapienza Univ Rome, Dept Internal Med & Med Specialties, Unit Dermatol, I-00185 Rome, Italy

[29] Univ Siena, S Maria Scotte Hosp, Dept Med Surg & Neurol Sci, Sect Dermatol, I-53100 Siena, Italy

[30] Univ Brescia, Dermatol Dept, I-25121 Brescia, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 10期

关键词：

Delphi; consensus; statement; brodalumab; psoriasis; NECROSIS-FACTOR-ALPHA; NAIL PSORIASIS; SYSTEMIC TREATMENT; CLINICAL-RESPONSE; PLAQUE PSORIASIS; SCALP PSORIASIS; HEART-FAILURE; DOUBLE-BLIND; PHASE-III; MANAGEMENT;

D O I：

10.3390/jcm12103545

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brodalumab is a recombinant, fully human immunoglobulin IgG2 monoclonal antibody specifically targeted against interleukin-17RA that has been approved for the treatment of moderate-to-severe psoriasis in Europe. We developed a Delphi consensus document focused on brodalumab for the treatment of moderate-to-severe psoriasis. Based on published literature and their clinical experience a steering committee drafted 17 statements covering 7 domains specific to the treatment of moderate-to-severe psoriasis with brodalumab. A panel of 32 Italian dermatologists indicated their level of agreement using a 5-point Likert scale (from 1 = "strongly disagree" to 5 = "strongly agree") using an online modified Delphi method. After the first round of voting (32 participants), positive consensus was reached for 15/17 (88.2%) of the proposed statements. Following a face-to-face virtual meeting, the steering committee decided that 5 statements would form "main principles" and 10 statements formed the final list. After a second round of voting, consensus was reached in 4/5 (80%) of the main principles and 8/10 (80%) for consensus statements. The final list of 5 main principles and 10 consensus statements identify key indications specific to the use of brodalumab in the treatment of moderate-to-severe psoriasis in Italy. These statements aid dermatologists in the management of patients with moderate-to-severe psoriasis.

引用

页数：15

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