New alpiniamide-type polyketide with antibiofilm activities from the marine-derived Streptomyces sp. ZS-A65

被引：2

作者：

Pu, Fanqi ^{[1
]}

Fang, Jiebin ^{[2
]}

Li, Wenshuo ^{[1
]}

Zhang, Bin ^{[1
]}

Hong, Xinyi ^{[1
]}

Xu, Lei ^{[1
]}

Li, Xihui ^{[1
]}

Jiang, Yongjun ^{[1
]}

机构：

[1] Zhejiang Ocean Univ, Sch Food & Pharm, Zhoushan 316021, Peoples R China

[2] Zhejiang Univ, Inst Marine Biol & Pharmacol, Ocean Coll, Zhoushan 316021, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 04期

基金：

中国国家自然科学基金;

关键词：

marine Streptomyces; Alpiniamides H-I; ECD calculations; antibiofilm; ALKALOIDS; BIOFILM;

D O I：

10.1002/cbdv.202400029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new alpiniamide-type polyketides, alpiniamides H-I (1-2), in addition to four recognized compounds, were discovered in Streptomyces sp. ZSA65 derived from the marine sediments. The planar structure and absolute configuration of alpiniamides H-I were elucidated using a combination of 1D, 2D NMR, HRESIMS data analysis, Mosher's method and ECD calculations. The antibiofilm and antibacterial activities against P. aeruginosa were evaluated using the microdilution method. Notably, Compound 2 exhibited strong antibiofilm property.

引用

页数：5