New alpiniamide-type polyketide with antibiofilm activities from the marine-derived Streptomyces sp. ZS-A65

被引：2
|
作者：
Pu, Fanqi [1 ]
Fang, Jiebin [2 ]
Li, Wenshuo [1 ]
Zhang, Bin [1 ]
Hong, Xinyi [1 ]
Xu, Lei [1 ]
Li, Xihui [1 ]
Jiang, Yongjun [1 ]
机构：
[1] Zhejiang Ocean Univ, Sch Food & Pharm, Zhoushan 316021, Peoples R China
[2] Zhejiang Univ, Inst Marine Biol & Pharmacol, Ocean Coll, Zhoushan 316021, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 04期
基金：
中国国家自然科学基金;
关键词：
marine Streptomyces; Alpiniamides H-I; ECD calculations; antibiofilm; ALKALOIDS; BIOFILM;
D O I：
10.1002/cbdv.202400029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new alpiniamide-type polyketides, alpiniamides H-I (1-2), in addition to four recognized compounds, were discovered in Streptomyces sp. ZSA65 derived from the marine sediments. The planar structure and absolute configuration of alpiniamides H-I were elucidated using a combination of 1D, 2D NMR, HRESIMS data analysis, Mosher's method and ECD calculations. The antibiofilm and antibacterial activities against P. aeruginosa were evaluated using the microdilution method. Notably, Compound 2 exhibited strong antibiofilm property.
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页数：5
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