Metabolic genes, a potential predictor of prognosis and immunogenicity of clear cell renal cell carcinoma

被引：0
|
作者：
Ji, Cheng-Jian [1 ]
Wei, Xi-Yi [1 ]
Yao, Liang-Yu [1 ]
Wang, Yi-Chun [1 ]
Cong, Rong [1 ]
Song, Ning-Hong [1 ,2 ,3 ]
机构：
[1] Nanjing Med Univ, Dept Urol, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Kezhou Peoples Hosp, Kezhou 845350, Xinjiang, Peoples R China
[3] Nanjing Med Univ, Dept Urol, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2023年 / 13卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Metabolic genes; ccRCC; prognosis; TME; PAFAH2; EXPRESSION; GLYCOLYSIS; GUIDELINES; THERAPIES; SIGNATURE; PATHWAYS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC). Many ccRCCs are diagnosed at an advanced stage due to the lack of early symptoms, with a high mortality rate and a poor prognosis. The occurrence and development of ccRCC are closely related to metabolic disorders. This study aims to explore the relationship between metabolic genes and prognosis, immune microenvironment, and tumor development of ccRCC. Using data from TCGA, GEO, and ArrayExpress, we successfully established a risk model (riskScore) based on 4 metabolic genes (MGs) that can accurately predict the prognosis and immune microenviron-ment of ccRCCs. In addition, we determined the role of PAFAH2 in suppressing tumor cell proliferation and migration in ccRCC in vitro. Our research may shed new light on ccRCC patients' prognosis and treatment management.
引用
收藏
页码：1387 / +
页数：25
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