The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy

被引：21
作者：
Gong, Yingying [1 ]
Bao, Lisha [1 ]
Xu, Tong [1 ]
Yi, Xiaofen [1 ]
Chen, Jinming [1 ]
Wang, Shanshan [1 ]
Pan, Zongfu [1 ,3 ,4 ]
Huang, Ping [1 ,3 ,4 ]
Ge, Minghua [2 ,3 ,4 ]
机构：
[1] Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Affiliated Peoples Hosp, Ctr Clin Pharm,Can Ctr,Dept Pharm, Hangzhou, Peoples R China
[2] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Otolaryngol & Head & Neck Ctr,Can Ctr,Dept Head &, Hangzhou, Peoples R China
[3] Zhejiang Prov Peoples Hosp, Key Lab Endocrine Gland Dis Zhejiang Prov, Hangzhou, Peoples R China
[4] Clin Res Ctr Canc Zhejiang Prov, Hangzhou, Peoples R China
来源：
MOLECULAR CANCER | 2023年 / 22卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Head and neck squamous cell carcinoma; Tumor ecosystem; Ecological therapy; CANCER-ASSOCIATED FIBROBLASTS; NEUTROPHIL EXTRACELLULAR TRAPS; LOCALLY ADVANCED HEAD; REGULATORY T-CELLS; SINGLE-CELL; IMMUNOSUPPRESSIVE MICROENVIRONMENT; TRANSCRIPTOMIC ANALYSIS; BIFIDOBACTERIUM-BREVE; METASTATIC HEAD; SELF-RENEWAL;
D O I：
10.1186/s12943-023-01769-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of head and neck squamous cell carcinoma (HNSCC) is a multi-step process, and its survival depends on a complex tumor ecosystem, which not only promotes tumor growth but also helps to protect tumor cells from immune surveillance. With the advances of existing technologies and emerging models for ecosystem research, the evidence for cell-cell interplay is increasing. Herein, we discuss the recent advances in understanding the interaction between tumor cells, the major components of the HNSCC tumor ecosystem, and summarize the mechanisms of how biological and abiotic factors affect the tumor ecosystem. In addition, we review the emerging ecological treatment strategy for HNSCC based on existing studies.
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页数：17
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