Interferon β1a treatment does not influence serum Epstein-Barr virus antibodies in patients with multiple sclerosis

被引：1
作者：
Lie, Ingrid Anne [1 ,2 ]
Rod, Brit Ellen [1 ,2 ]
Kvistad, Silje Stokke [2 ,3 ]
Holmoy, Trygve [4 ,5 ]
Myhr, Kjell-Morten [1 ,2 ]
Torkildsen, Oivind [1 ,2 ]
Wergeland, Stig [1 ,2 ,6 ]
机构：
[1] Univ Bergen, Dept Clin Med, Bergen, Norway
[2] Haukeland Hosp, Dept Neurol, Neurosysmed, Bergen, Norway
[3] Haukeland Hosp, Dept Immunol & Transfus Med, Bergen, Norway
[4] Univ Oslo, Inst Clin Med, Oslo, Norway
[5] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
[6] Haukeland Hosp, Norwegian MS Registry & Biobank, Bergen, Norway
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2023年 / 70卷
关键词：
Multiple sclerosis; Interferons; Epstein-Barr virus; Herpesviridae; EBNA-1; DISEASE-ACTIVITY; THERAPY; EBV;
D O I：
10.1016/j.msard.2023.104530
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
There is increasing evidence of Epstein-Barr virus (EBV) being conditional in multiple sclerosis (MS) pathogenesis and influential for disease activity. Interferon-beta (IFN beta) is a cytokine with antiviral effects used to treat MS, in which a possible antiviral effect against EBV has been questioned. In this study, we investigated the effect of IFN beta-1a treatment on serum EBV antibody levels in 84 patients with relapsing-remitting MS. In the 18 months following IFN beta-1a treatment initiation, there were no significant associations between treatment and serum levels of Epstein-Barr nuclear antigen 1 (EBNA-1) immunoglobulin (Ig) G, early antigen (EA) IgG, viral capsid antigen (VCA) IgG or VCA IgM. The findings suggest that IFN beta-1a treatment does not influence the humoral response to EBV in patients with MS.
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