Dynamical Analysis of Generalized Tumor Model with Caputo Fractional-Order Derivative

被引:56
作者
Padder, Ausif [1 ]
Almutairi, Laila [2 ]
Qureshi, Sania [3 ,4 ,5 ]
Soomro, Amanullah [3 ]
Afroz, Afroz [6 ]
Hincal, Evren [4 ]
Tassaddiq, Asifa [7 ]
机构
[1] Guru Nanak Univ, Univ Inst Engn & Technol, Dept Appl Sci, Hyderabad 501506, India
[2] Majmaah Univ, Coll Comp & Informat Sci, Dept Comp Engn, Al Majmaah 11952, Saudi Arabia
[3] Mehran Univ Engn & Technol, Dept Basic Sci & Related Studies, Jamshoro 76062, Pakistan
[4] Near East Univ, Dept Math, TR-99138 Mersin, Turkiye
[5] Lebanese Amer Univ, Dept Comp Sci & Math, Beirut, Lebanon
[6] Maulana Azad Natl Urdu Univ, Dept Math, Hyderabad 500032, India
[7] Majmaah Univ, Coll Comp & Informat Sci, Dept Basic Sci & Humanities, Al Majmaah 11952, Saudi Arabia
关键词
tumor-immune interaction; Caputo fractional derivative; stability analysis; parameter fitting; numerical simulation; STABILITY ANALYSIS; IMMUNE-SYSTEM; MACROPHAGE POLARIZATION; GROWTH;
D O I
10.3390/fractalfract7030258
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
In this study, we perform a dynamical analysis of a generalized tumor model using the Caputo fractional-order derivative. Tumor growth models are widely used in biomedical research to understand the dynamics of tumor development and to evaluate potential treatments. The Caputo fractional-order derivative is a mathematical tool that is recently being applied to model biological systems, including tumor growth. We present a detailed mathematical analysis of the generalized tumor model with the Caputo fractional-order derivative and examine its dynamical behavior. Our results show that the Caputo fractional-order derivative provides a more accurate description of the tumor growth dynamics compared to classical integer-order derivatives. We also provide a comprehensive stability analysis of the tumor model and show that the fractional-order derivative allows for a more nuanced understanding of the stability of the system. The least-square curve fitting method fits several biological parameters, including the fractional-order parameter a. In conclusion, our study provides new insights into the dynamics of tumor growth and highlights the potential of the Caputo fractional-order derivative as a valuable tool in biomedical research. The results of this study shall have significant implications for the development of more effective treatments for tumor growth and the design of more accurate mathematical models of tumor development.
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页数:19
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