YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

被引：165
作者：
Piccolo, Stefano [1 ,2 ]
Panciera, Tito [1 ]
Contessotto, Paolo [1 ]
Cordenonsi, Michelangelo [1 ]
机构：
[1] Univ Padua, Dept Mol Med, Padua, Italy
[2] IFOM ETS, AIRC Inst Mol Oncol, Milan, Italy
来源：
NATURE CANCER | 2023年 / 4卷 / 01期
关键词：
INTESTINAL STEM-CELL; YES-ASSOCIATED PROTEIN-1; HIPPO SIGNALING PATHWAY; UVEAL MELANOMA; MOUSE MODEL; ACTIN-BINDING; EFFECTORS YAP; BREAST-CANCER; TARGETING YAP; DNA-DAMAGE;
D O I：
10.1038/s43018-022-00473-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and highlight open questions. YAP/ TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials.
引用
收藏
页码：9 / 26
页数：18
相关论文
共 217 条
[81]   Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics [J].
Kadoch, Cigall ;
Crabtree, Gerald R. .
SCIENCE ADVANCES, 2015, 1 (05)
[82]   Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse [J].
Kalamarides, M ;
Niwa-Kawakita, M ;
Leblois, H ;
Abramowski, V ;
Perricaudet, M ;
Janin, A ;
Thomas, G ;
Gutmann, DH ;
Giovannini, M .
GENES & DEVELOPMENT, 2002, 16 (09) :1060-1065
[83]  
Kaneda A, 2020, AM J CANCER RES, V10, P4399
[84]  
Kapoor A, 2014, CELL, V158, P185, DOI [10.1016/j.cell.2014.06.003, 10.1016/j.cell.2019.10.037]
[85]   ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration [J].
Kidiyoor, Gururaj Rao ;
Li, Qingsen ;
Bastianello, Giulia ;
Bruhn, Christopher ;
Giovannetti, Irene ;
Mohamood, Adhil ;
Beznoussenko, Galina V. ;
Mironov, Alexandre ;
Raab, Matthew ;
Piel, Matthieu ;
Restuccia, Umberto ;
Matafora, Vittoria ;
Bachi, Angela ;
Barozzi, Sara ;
Parazzoli, Dario ;
Frittoli, Emanuela ;
Palamidessi, Andrea ;
Panciera, Tito ;
Piccolo, Stefano ;
Scita, Giorgio ;
Maiuri, Paolo ;
Havas, Kristina M. ;
Zhou, Zhong-Wei ;
Kumar, Amit ;
Bartek, Jiri ;
Wang, Zhao-Qi ;
Foiani, Marco .
NATURE COMMUNICATIONS, 2020, 11 (01)
[86]   YAP, CTGF and Cyr61 are overexpressed in tamoxifen-resistant breast cancer and induce transcriptional repression of ERα [J].
Kim, Hyungjoo ;
Son, Seogho ;
Ko, Yunhyo ;
Lee, Jeong Eon ;
Kim, Sangmin ;
Shin, Incheol .
JOURNAL OF CELL SCIENCE, 2021, 134 (11)
[87]   Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation [J].
Kim, Min Hwan ;
Kim, Jongshin ;
Hong, Hyowon ;
Lee, Si-Hyung ;
Lee, June-Koo ;
Jung, Eunji ;
Kim, Joon .
EMBO JOURNAL, 2016, 35 (05) :462-478
[88]   Rho-Kinase as a Target for Cancer Therapy and Its Immunotherapeutic Potential [J].
Kim, Seohyun ;
Kim, Seong A. ;
Han, Jihoon ;
Kim, In-San .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (23)
[89]   Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma [J].
Kim, Wantae ;
Khan, Sanjay Kumar ;
Liu, Yuchen ;
Xu, Ruoshi ;
Park, Ogyi ;
He, Yong ;
Cha, Boksik ;
Gao, Bin ;
Yang, Yingzi .
GUT, 2018, 67 (09) :1692-1703
[90]   Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells [J].
Konsavage, Wesley M., Jr. ;
Kyler, Sydney L. ;
Rennoll, Sherri A. ;
Jin, Ge ;
Yochum, Gregory S. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (15) :11730-11739
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