YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

被引：161
作者：
Piccolo, Stefano [1 ,2 ]
Panciera, Tito [1 ]
Contessotto, Paolo [1 ]
Cordenonsi, Michelangelo [1 ]
机构：
[1] Univ Padua, Dept Mol Med, Padua, Italy
[2] IFOM ETS, AIRC Inst Mol Oncol, Milan, Italy
来源：
NATURE CANCER | 2023年 / 4卷 / 01期
关键词：
INTESTINAL STEM-CELL; YES-ASSOCIATED PROTEIN-1; HIPPO SIGNALING PATHWAY; UVEAL MELANOMA; MOUSE MODEL; ACTIN-BINDING; EFFECTORS YAP; BREAST-CANCER; TARGETING YAP; DNA-DAMAGE;
D O I：
10.1038/s43018-022-00473-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and highlight open questions. YAP/ TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials.
引用
收藏
页码：9 / 26
页数：18
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