YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

被引：156

作者：

Piccolo, Stefano ^{[1
,2
]}

Panciera, Tito ^{[1
]}

Contessotto, Paolo ^{[1
]}

Cordenonsi, Michelangelo ^{[1
]}

机构：

[1] Univ Padua, Dept Mol Med, Padua, Italy

[2] IFOM ETS, AIRC Inst Mol Oncol, Milan, Italy

来源：

NATURE CANCER | 2023年 / 4卷 / 01期

关键词：

INTESTINAL STEM-CELL; YES-ASSOCIATED PROTEIN-1; HIPPO SIGNALING PATHWAY; UVEAL MELANOMA; MOUSE MODEL; ACTIN-BINDING; EFFECTORS YAP; BREAST-CANCER; TARGETING YAP; DNA-DAMAGE;

D O I：

10.1038/s43018-022-00473-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and highlight open questions. YAP/ TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials.

引用

页码：9 / 26

页数：18

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