Terahertz in vivo imaging of human skin: Toward detection of abnormal skin pathologies

被引:4
|
作者
Qi, X. [1 ]
Bertling, K. [1 ]
Torniainen, J. [1 ]
Kong, F. [2 ]
Gillespie, T. [1 ]
Primiero, C. [2 ]
Stark, M. S. [2 ]
Dean, P. [3 ]
Indjin, D. [3 ]
Li, L. H. [3 ]
Linfield, E. H. [3 ]
Davies, A. G. [3 ]
Brunig, M. [1 ]
Mills, T. [4 ]
Rosendahl, C. [5 ]
Soyer, H. P. [2 ]
Rakic, A. D. [1 ]
机构
[1] Univ Queensland, Sch Elect Engn & Comp Sci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Frazer Inst, Dermatol Res Ctr, Woolloongabba, Qld 4102, Australia
[3] Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, England
[4] OscillaDx Pty Ltd, Brisbane, Qld, Australia
[5] Univ Queensland, Fac Med, Gen Practice Clin Unit, Herston, Qld 4029, Australia
基金
澳大利亚研究理事会; 英国工程与自然科学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
LASER FEEDBACK INTERFEROMETRY; CONFOCAL MICROSCOPY; DIAGNOSTIC-ACCURACY; EX-VIVO; SPECTROSCOPY;
D O I
10.1063/5.0190573
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Terahertz (THz) imaging has long held promise for skin cancer detection but has been hampered by the lack of practical technological implementation. In this article, we introduce a technique for discriminating several skin pathologies using a coherent THz confocal system based on a THz quantum cascade laser. High resolution in vivo THz images (with diffraction limited to the order of 100 mu m) of several different lesion types were acquired and compared against one another using the amplitude and phase values. Our system successfully separated pathologies using a combination of phase and amplitude information and their respective surface textures. The large scan field (50 x 40 mm) of the system allows macroscopic visualization of several skin lesions in a single frame. Utilizing THz imaging for dermatological assessment of skin lesions offers substantial additional diagnostic value for clinicians. THz images contain information complementary to the information contained in the conventional digital images.
引用
收藏
页数:10
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