Vitamin B12 is associated negatively with anemia in older Chinese adults with a low dietary diversity level: evidence from the Healthy Ageing and Biomarkers Cohort Study (HABCS)

被引:2
作者
Liu, Ling [1 ]
Zhou, Jinhui [2 ]
Chen, Chen [3 ]
Qu, Yingli [2 ]
Wang, Jun [2 ]
Lu, Feng [3 ]
Liu, Yingchun [2 ]
Cai, Jiayi [2 ]
Ji, Saisai [2 ]
Li, Yawei [2 ]
Gu, Heng [2 ]
Zhao, Feng [2 ]
Lyu, Yuebin [2 ]
Shi, Xiaoming [2 ]
机构
[1] Hosp Beijing Forestry Univ, Beijing 100083, Peoples R China
[2] Chinese Ctr Dis Control & Prevent, Natl Inst Environm Hlth, China CDC Key Lab Environm & Populat Hlth, 7 Panjiayuan Nanli, Chaoyang 100021, Beijing, Peoples R China
[3] Beijing Municipal Hlth Commiss Policy Res Ctr, Beijing Municipal Hlth Commiss Informat Ctr, Beijing 100034, Peoples R China
关键词
Chinese older adults; Vitamin B-12; Anemia; Dietary diversity score (DDS); COBALAMIN DEFICIENCY; MORTALITY; FOLATE; HOMOCYSTEINE; CONSUMPTION; B12; AGE; PREVALENCE; FREQUENCY; DIAGNOSIS;
D O I
10.1186/s12877-023-04586-7
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective The associations between plasma vitamin B-12 level and anemia under different dietary patterns in elderly Chinese people are poorly understood. We aimed to examine the associations between plasma vitamin B-12 levels and anemia under different dietary patterns in adults aged 65 years and older in nine longevity areas in China. Methods A total of 2405 older adults completed a food frequency questionnaire at the same time as a face-to-face interview. The dietary diversity score (DDS) was assessed based on the food frequency questionnaire, with the low DDS group referring to participants with a DDS score <= 4 points. Vitamin B-12 levels were divided into two groups of high (>295 pg/mL) and low (<= 295 pg/mL) with the median used as the cut-off point. Sub-analyses were also performed on older adults divided into tertiles of vitamin B12 levels: low (< 277 pg/mL), medium (277-375 pg/mL) and high (> 375 pg/mL) to study the association of these levels with anemia. Results Six hundred ninety-five (28.89%) of these people were diagnosed with anemia and had a mean age of 89.3 years. Higher vitamin B-12 levels were associated with a decreased risk of anemia (multi-adjusted OR, 0.59, [95% CI, 0.45 similar to 0.77] P < 0.001) in older adults with a low DDS, whereas no significant association between vitamin B-12 levels and anemia was found in older adults with a high DDS in a full-model after adjustment for various confounding factors (multi-adjusted OR, 0.88, [95% CI, 0.65 similar to 1.19], P = 0.41). Conclusion The relationship between vitamin B-12 levels and the prevalence of anemia was significant only when the level of dietary diversity in the older adults was relatively low. The dietary structure of the population should be taken into consideration in combination in order to effectively improve anemia status by supplementing vitamin B-12.
引用
收藏
页数:11
相关论文
共 54 条
  • [1] No association between subnormal serum vitamin B12 and anemia in older nursing home patients
    Abrahamsen, Jenny Foss
    Monsen, Anne-Lise Bjorke
    Ranhoff, Anette Hylen
    Nilsen, Roy M.
    Engtro, Einar
    Rekdal, Magne
    Kruger, Kjell
    [J]. EUROPEAN GERIATRIC MEDICINE, 2020, 11 (02) : 247 - 254
  • [2] State of the art review: oral and nasal vitamin B12 therapy in the elderly
    Andres, E.
    Zulfiqar, A. -A.
    Vogel, T.
    [J]. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2020, 113 (01) : 5 - 15
  • [3] Vitamin B12 (cobalamin) deficiency in elderly patients
    Andrès, E
    Loukili, NH
    Noel, E
    Kaltenbach, G
    Ben Abdelgheni, M
    Perrin, AE
    Noblet-Dick, M
    Maloisel, F
    Schlienger, JL
    Blicklé, JF
    [J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 2004, 171 (03) : 251 - 259
  • [4] [Anonymous], 2011, Guidelines for measuring household and individual dietary diversity
  • [5] Unexpected high plasma cobalamin
    Arendt, Johan F. B.
    Nexo, Ebba
    [J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2013, 51 (03) : 489 - 496
  • [6] Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort
    Bach, Veronika
    Schruckmayer, Guenter
    Sam, Ines
    Kemmler, Georg
    Stauder, Reinhard
    [J]. CLINICAL INTERVENTIONS IN AGING, 2014, 9 : 1187 - 1196
  • [7] Prevalence and outcomes of anemia in geriatrics:: A systematic review of the literature
    Beghé, C
    Wilson, A
    Ershler, WB
    [J]. AMERICAN JOURNAL OF MEDICINE, 2004, 116 : 3 - 10
  • [8] Characteristics of patients admitted to internal medicine departments with high serum cobalamin levels: Results from a prospective cohort study
    Brah, Souleymane
    Chiche, Laurent
    Mancini, Julien
    Meunier, Benoit
    Arlet, Jean-Benoit
    [J]. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2014, 25 (05) : E57 - E58
  • [9] Folic acid fortification: is masking of vitamin B-12 deficiency what we should really worry about?
    Brouwer, Ingeborg
    Verhoef, Petra
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 86 (04) : 897 - 898
  • [10] Carmel R, 2001, AM J GASTROENTEROL, V96, P63, DOI 10.1111/j.1572-0241.2001.03453.x