Toll-like receptors in inflammatory bowel disease: A review of the role of phytochemicals

被引:10
作者
Esmaealzadeh, Niusha [1 ]
Ram, Mahboobe [2 ,3 ]
Abdolghaffari, Amirhossein [4 ,5 ]
Marques, Andre Mesquita [6 ]
Bahramsoltani, Roodabeh [1 ,3 ,7 ]
机构
[1] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, Tehran, Iran
[2] Pasteur Inst Iran, Biotechnol Res Ctr, Med Biotechnol Dept, Drug Design & Bioinformat Unit, Tehran, Iran
[3] Universal Sci Educ & Res Network USERN, PhytoPharmacol Interest Grp PPIG, Tehran, Iran
[4] Islamic Azad Univ, Fac Pharm, Dept Toxicol & Pharmacol, Tehran Med Sci, Tehran, Iran
[5] Universal Sci Educ & Res Network USERN, GI Pharmacol Interest Grp GPIG, Tehran, Iran
[6] Fiocruz MS, Inst Drug Technol Farmanguinhos, Dept Nat Prod, Rio De Janeiro, Brazil
[7] 27 Felestin Sq,POB 1416663361, Tehran, Iran
关键词
Colitis; Herbal medicine; Traditional medicine; Inflammation; Oxidative stress; NF-KAPPA-B; TNBS-INDUCED COLITIS; REGULATORY T-CELLS; INHIBITING LIPOPOLYSACCHARIDE-BINDING; INDUCED ULCERATIVE-COLITIS; DRUG-DELIVERY SYSTEM; ACID-INDUCED COLITIS; DSS-INDUCED COLITIS; IN-VITRO; ANTIINFLAMMATORY ACTIVITY;
D O I
10.1016/j.phymed.2023.155178
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Background: Inflammatory bowel disease (IBD) is a chronic inflammation within the gastrointestinal tract with a remarkable impact on patients' quality of life. Toll-like receptors (TLR), as a key contributor of immune system in inflammation, has a critical role in the pathogenesis of IBD and thus, can be a suitable target of therapeutic agents. Medicinal plants have long been considered as a source of bioactive agents for different diseases, including IBD. Purpose: This review discusses current state of the art on the role of plant-derived compounds for the manage-ment of IBD with a focus on TLRs. Methods: Electronic database including PubMed, Web of Science, and Scopus were searched up to January 2023 and all studies in which anticolitis effects of a phytochemical was assessed via modulation of TLRs were considered. Results: Different categories of phytochemicals, including flavonoids, lignans, alkaloids, terpenes, saccharides, and saponins have demonstrated modulatory effects on TLR in different animal and cell models of bowel inflammation. Flavonoids were the most studied phytochemicals amongst others. Also, TLR4 was the most important type of TLRs which were modulated by phytochemicals. Other mechanisms such as inhibition of pro -inflammatory cytokines, nuclear factor-kappa B pathway, nitric oxide synthesis pathway, cyclooxygenase-2, lipid peroxidation, as well as induction of endogenous antioxidant defense mechanisms were also reported for phy-tochemicals in various IBD models. Conclusion: Taken together, a growing body of pre-clinical evidence support the efficacy of herbal compounds for the treatment of IBD via modulation of TLRs. Future clinical studies are recommended to assess the safety and efficacy of these compounds in human.
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页数:33
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