Altered single-subject gray matter structural networks in first-episode drug-naïve adolescent major depressive disorder

被引:11
作者
Wu, Baolin [1 ,2 ]
Chen, Ying [1 ,2 ]
Long, Xipeng [3 ]
Cao, Yuan [3 ]
Xie, Hongsheng [3 ]
Wang, Xiuli [4 ]
Roberts, Neil [5 ]
Gong, Qiyong [1 ,2 ,6 ]
Jia, Zhiyun [3 ]
机构
[1] West China Hosp Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, Funct & Mol Imaging Key Lab Sichuan Prov, Chengdu, Peoples R China
[2] Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu, Peoples R China
[3] Sichuan Univ, Dept Nucl Med, West China Hosp, Chengdu, Peoples R China
[4] Fourth Peoples Hosp Chengdu, Dept Clin Psychol, Chengdu, Peoples R China
[5] Univ Edinburgh, Sch Clin Sci, Queens Med Res Inst QMRI, Edinburgh EH8 9YL, Midlothian, Scotland
[6] Sichuan Univ, Dept Radiol, West China Xiamen Hosp, Xiamen, Peoples R China
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
Major depressive disorder; Graph theory; Connectome; Gray matter networks; Structural magnetic resonance imaging; BRAIN-DEVELOPMENT; 1ST EPISODE; NAIVE; YOUTH;
D O I
10.1016/j.psychres.2023.115557
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Although previous studies have demonstrated regional gray matter (GM) structural abnormalities in adolescents with major depressive disorder (MDD), how the topological organization of GM networks is affected in these patients is still unclear. Structural magnetic resonance imaging data were acquired from 100 first-episode drugnaive adolescent MDD patients and 80 healthy controls (HCs). Whole-brain GM structural network was constructed for each subject, and a graph theory analysis was used to calculate the topological metrics of GM networks. Adolescent MDD patients showed significantly lower cluster coefficient and local efficiency compared to HCs. Compared to controls, adolescent MDD patients showed higher nodal centralities in the bilateral cuneus, left lingual gyrus, and right middle occipital gyrus and lower nodal centralities in the bilateral dorsolateral superior frontal gyrus, bilateral middle frontal gyrus, right anterior cingulate and paracingulate gyri, bilateral hippocampus, bilateral amygdala, bilateral caudate nucleus, and bilateral thalamus. Nodal centralities of the hippocampus were negatively associated with symptom severity and illness duration. Our findings suggest disrupted topological organization of GM structural networks in adolescent MDD patients. Impaired local segregation and abnormal nodal centralities in the prefrontal-subcortical-limbic areas and visual cortex regions may play important roles in the neurobiology of adolescent-onset MDD.
引用
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页数:7
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