Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview

被引:47
作者
Santulli, Gaetano [1 ,2 ]
Kansakar, Urna [1 ]
Varzideh, Fahimeh [2 ]
Mone, Pasquale [2 ]
Jankauskas, Stanislovas S. [1 ]
Lombardi, Angela [1 ]
机构
[1] Albert Einstein Coll Med, Fle Inst Diabet & Metab FIDAM, Einstein Inst Aging Res, Einstein Mt Sinai Diabet Res Ctr ES DRC,Dept Med, New York, NY 10461 USA
[2] Albert Einstein Coll Med, Wilf Family Cardiovasc Res Inst, Dept Mol Pharmacol, Div Cardiol, New York, NY 10461 USA
关键词
aging; 2-aminoethanesulfonic acid; cardiovascular risk; energy drinks; inflammation; metabolism; oxidative stress; supplements; tauric acid; taurine; SULFINIC ACID DECARBOXYLASE; ENDOPLASMIC-RETICULUM STRESS; IMPROVES INSULIN SENSITIVITY; CONGESTIVE-HEART-FAILURE; CARDIAC OXIDATIVE STRESS; MESENCHYMAL STEM-CELLS; DIETARY TAURINE; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; SECRETORY PHENOTYPE;
D O I
10.3390/nu15194236
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Taurine, a naturally occurring sulfur-containing amino acid, has attracted significant attention in recent years due to its potential health benefits. Found in various foods and often used in energy drinks and supplements, taurine has been studied extensively to understand its impact on human physiology. Determining its exact functional roles represents a complex and multifaceted topic. We provide an overview of the scientific literature and present an analysis of the effects of taurine on various aspects of human health, focusing on aging and cardiovascular pathophysiology, but also including athletic performance, metabolic regulation, and neurological function. Additionally, our report summarizes the current recommendations for taurine intake and addresses potential safety concerns. Evidence from both human and animal studies indicates that taurine may have beneficial cardiovascular effects, including blood pressure regulation, improved cardiac fitness, and enhanced vascular health. Its mechanisms of action and antioxidant properties make it also an intriguing candidate for potential anti-aging strategies.
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页数:18
相关论文
共 230 条
[1]   A Novel Role of SIRT1/ FGF-21 in Taurine Protection Against Cafeteria Diet-Induced Steatohepatitis in Rats [J].
Abd Elwahab, Azza H. ;
Ramadan, Basma K. ;
Schaalan, Mona F. ;
Tolba, Amina M. .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 43 (02) :644-659
[2]   Effects of chronic taurine treatment on reactivity of the rat aorta [J].
Abebe, W ;
Mozaffari, MS .
AMINO ACIDS, 2000, 19 (3-4) :615-623
[3]   Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70 [J].
Abud, Gabriela Ferreira ;
De Carvalho, Flavia Giolo ;
Batitucci, Gabriela ;
Travieso, Sofia Germano ;
Bueno Junior, Carlos Roberto ;
Barbosa Junior, Fernando ;
Marchini, Julio Sergio ;
de Freitas, Ellen Cristini .
NUTRITION, 2022, 101
[4]  
Ahmadian M, 2017, THER ADV CARDIO DIS, V11, P185, DOI 10.1177/1753944717711138
[5]  
Ahmadian Mehdi, 2017, Journal of Dietary Supplements, V14, P422, DOI [10.1080/19390211.2016.1267059, 10.1080/19390211.2016.1267059]
[6]   Cytoprotective effect of taurine against sodium chlorate-induced oxidative damage in human red blood cells: an ex vivo study [J].
Ali, Shaikh Nisar ;
Arif, Amin ;
Ansari, Fariheen Aisha ;
Mahmood, Riaz .
AMINO ACIDS, 2022, 54 (01) :33-46
[7]   Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance [J].
Anuradha, CV ;
Balakrishnan, SD .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1999, 77 (10) :749-754
[8]   Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells [J].
Askwith, Trevor ;
Zeng, Wei ;
Eggo, Margaret C. ;
Stevens, Martin J. .
EXPERIMENTAL NEUROLOGY, 2012, 233 (01) :154-162
[9]   THERAPEUTIC EFFECT OF TAURINE IN CONGESTIVE HEART-FAILURE - A DOUBLE-BLIND CROSSOVER TRIAL [J].
AZUMA, J ;
SAWAMURA, A ;
AWATA, N ;
OHTA, H ;
HAMAGUCHI, T ;
HARADA, H ;
TAKIHARA, K ;
HASEGAWA, H ;
YAMAGAMI, T ;
ISHIYAMA, T ;
IWATA, H ;
KISHIMOTO, S .
CLINICAL CARDIOLOGY, 1985, 8 (05) :276-282
[10]   USEFULNESS OF TAURINE IN CHRONIC CONGESTIVE-HEART-FAILURE AND ITS PROSPECTIVE APPLICATION [J].
AZUMA, J ;
SAWAMURA, A ;
AWATA, N .
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1992, 56 (01) :95-99